List of Famous people born in Plattsburgh, United States of America

Jean Arthur was an American Broadway and film actress whose career began in silent films in the 1920s and lasted until the early 1950s.

Karen Elizabeth Wetterhahn (October 16, 1948 – June 8, 1997) was an American professor of chemistry at Dartmouth College, New Hampshire who specialized in toxic metal exposure. She died of mercury poisoning at the age of 48 due to accidental exposure to the organic mercury compound dimethylmercury (Hg(CH₃)₂). Protective gloves in use at the time of the incident provided insufficient protection, and exposure to only a few drops of the chemical absorbed through the gloves proved to be fatal after less than a year.

Terry Ronald LaValley is an American prelate of the Roman Catholic Church. He is the current Bishop of Ogdensburg.

Julia Spencer-Fleming is an American novelist of Mystery fiction. She has won the Agatha Award, Anthony Award, Macavity Awards, Dilys Award, Barry Award, the Nero Award, and Gumshoe Awards. She has also been a finalist for the Edgar Award. Her books feature Clare Fergusson, a retired helicopter pilot turned Episcopal priest and Russ Van Alstyne, a police chief. They are set in Millers Kill, a fictional town in upstate New York.

Michael Phillip Anderson was a United States Air Force officer and NASA astronaut. Anderson and his six fellow crew members were killed in the Space Shuttle Columbia disaster when the craft disintegrated during its re-entry into the Earth's atmosphere. Anderson served as the payload commander and lieutenant colonel in charge of science experiments on the Columbia. Anderson was posthumously awarded the Congressional Space Medal of Honor.

David Lorge Parnas is a Canadian early pioneer of software engineering, who developed the concept of information hiding in modular programming, which is an important element of object-oriented programming today. He is also noted for his advocacy of precise documentation.