List of Famous people born in Pennsylvania, United States of America

Molly Ephraim is an American actress who has appeared in films, television, and Broadway, Off-Broadway, and regional theater productions. She is known for her role as Mandy Baxter in the ABC sitcom Last Man Standing during its original run (2011–2017). Ephraim has also appeared in a number of other TV series including Brockmire (2017), Halt and Catch Fire (2017), and Casual (2018). Most recently, Ephraim portrayed Irene Kelly in The Front Runner (2018), her second collaboration with Last Man Standing co-star Kaitlyn Dever. She is currently appearing in HBO’s Perry Mason as Della Street’s lover Hazel Prystock.

Ira Samuel Einhorn, known as "The Unicorn Killer", was a convicted murderer and American environmental activist. He was convicted of murdering his ex-girlfriend, Holly Maddux. On September 9, 1977, Maddux disappeared following a trip to collect her belongings from the apartment she and Einhorn had shared in Philadelphia, Pennsylvania. Eighteen months later, police found her partially mummified body in a trunk in Einhorn's closet.

De'Andre James Hunter is an American professional basketball player for the Atlanta Hawks of the National Basketball Association (NBA). He played college basketball for the Virginia Cavaliers where they won the National Championship in 2019.

William Mills Wrigley Jr. was an American chewing gum industrialist. He was founder and eponym of the Wm. Wrigley Jr. Company in 1891.

Russell David Johnson was an American actor, known for his role as Professor Roy Hinkley in Gilligan's Island. He was also known for Marshal Gib Scott in Black Saddle.

Vanita Gupta is an American civil rights attorney. She is the president and chief executive officer of the Leadership Conference on Civil and Human Rights. From 2014 to 2017, she served as the principal deputy assistant attorney general and head of the Civil Rights Division at the U.S. Department of Justice, where she was the chief civil rights prosecutor for the United States.

Rachel Louise Carson was an American marine biologist, author, and conservationist whose book Silent Spring and other writings are credited with advancing the global environmental movement.

George Edward Waddell was an American southpaw pitcher in Major League Baseball (MLB). Over a career spanning 13 years, he played for the Louisville Colonels, Pittsburgh Pirates, and Chicago Orphans in the National League, as well as the Philadelphia Athletics and St. Louis Browns in the American League. Born in Bradford, Pennsylvania, Waddell was elected to the Baseball Hall of Fame in 1946.

Adam Frederick Goldberg is an American television and film producer and writer, best known as the creator and showrunner of the television series Breaking In, Imaginary Mary, Schooled, and The Goldbergs, the last of which is based on his own childhood.

Michael Cole Mussina, nicknamed "Moose", is an American former baseball starting pitcher who played 18 seasons in Major League Baseball (MLB) for the Baltimore Orioles (1991–2000) and the New York Yankees (2001–2008). He was elected to the Baseball Hall of Fame in his sixth year of eligibility in 2019.