List of Famous people born in Pennsylvania, United States of America

Bruce M. Clark is a former American college and professional football player who was a defensive end in the Canadian Football League (CFL) and National Football League (NFL) for ten seasons during the 1980s. Clark played college football at Penn State University, where he was an All-American. He was the fourth pick overall in the 1980 NFL Draft, but chose to play for the CFL's Toronto Argonauts before joining the NFL's New Orleans Saints and Kansas City Chiefs.

Jay T. Last is a physicist, silicon pioneer, and member of the so-called "traitorous eight" that founded Silicon Valley.

Carol Ann Mansell is an American film and television actress, best known for her first television role: Ethel MacDoogan, the main character in the sitcom Down to Earth, running on WTBS from 1983 to 1987.

Charles Dera is an American pornographic actor, stripper, and model.

Helene Hanff was an American writer born in Philadelphia, Pennsylvania. She is best known as the author of the book 84, Charing Cross Road, which became the basis for a stage play, television play, and film of the same name.

Jason "Jay" Mehler is an American musician. He played guitar in British rock band Kasabian from 2006 to 2013, when he quit to become a touring member of Beady Eye, until their disbanding in late 2014. Mehler continued as a session and touring musician for Liam Gallagher since 2017.

William Woodville Rockhill was a United States diplomat, best known as the author of the U.S.'s Open Door Policy for China, the first American to learn to speak Tibetan, and one of the West's leading experts on the modern political history of China.

Lionel James "L-Train" Simmons is an American former professional basketball player.

Edward Drinker Cope was an American paleontologist and comparative anatomist, as well as a noted herpetologist and ichthyologist. He was a founder of the Neo-Lamarckism school of thought. Born to a wealthy Quaker family, Cope distinguished himself as a child prodigy interested in science; he published his first scientific paper at the age of 19. Though his father tried to raise Cope as a gentleman farmer, he eventually acquiesced to his son's scientific aspirations. Cope married his cousin and had one child; the family moved from Philadelphia to Haddonfield, New Jersey, although Cope would maintain a residence and museum in Philadelphia in his later years.

Craig Shoemaker is an American stand-up comedian, actor, author, writer, and producer, with a career in show business spanning over three decades. He was named Comedian of the Year at The American Comedy Awards on ABC and garnered two NATAS Emmy awards. His 90-minute stand-up special, Daditude, aired on Showtime and Netflix.