List of Famous people born in Pennsylvania, United States of America

Ernest Davis was an American football player, a halfback who won the Heisman Trophy in 1961 and was its first African-American recipient. Davis played college football for Syracuse University and was the first pick in the 1962 NFL Draft, where he was selected by the Cleveland Browns. Davis was diagnosed with leukemia that same year, and died shortly after at age 23 without ever playing in a professional game. He was inducted into the College Football Hall of Fame in 1979 and was the subject of the 2008 film The Express: The Ernie Davis Story.

George Kenneth Griffey Jr., nicknamed "Junior" and "the Kid", is an American former professional baseball outfielder who played 22 years in Major League Baseball (MLB). He spent most of his career with the Seattle Mariners and Cincinnati Reds, along with a short stint with the Chicago White Sox. A member of the Baseball Hall of Fame and a 13-time All-Star, Griffey is one of the most prolific home run hitters in baseball history; his 630 home runs rank as the seventh-most in MLB history. Griffey was also an exceptional defender and won 10 Gold Glove Awards in center field. He is tied for the record of most consecutive games with a home run.

James Edward Kelly is a former American football quarterback who played in the National Football League (NFL) for eleven seasons with the Buffalo Bills. He also played two seasons with the Houston Gamblers in the United States Football League (USFL).

Elizabeth Cochrane Seaman, better known by her pen name Nellie Bly, was an American journalist, industrialist, inventor, and charity worker who was widely known for her record-breaking trip around the world in 72 days, in emulation of Jules Verne's fictional character Phileas Fogg, and an exposé in which she worked undercover to report on a mental institution from within. She was a pioneer in her field and launched a new kind of investigative journalism.

Zachary John Quinto is an American actor and film producer. He is known for his roles as Sylar, the primary antagonist from the science fiction drama series Heroes (2006–2010), Spock in the film Star Trek (2009) and its sequels Star Trek Into Darkness (2013) and Star Trek Beyond (2016), Charlie Manx in the AMC series NOS4A2, as well as his Emmy nominated performance in American Horror Story: Asylum. His other film roles include Margin Call, What's Your Number?, Hitman: Agent 47, Snowden, and Hotel Artemis. He also appeared in smaller roles on television series such as So NoTORIous, The Slap, and 24, and on stage in Angels in America, The Glass Menagerie, and Smokefall.

Dane William DeHaan is an American actor, known for his roles as Andrew Detmer in Chronicle (2012), Harry Osborn / Green Goblin in The Amazing Spider-Man 2 (2014), Lockhart in A Cure for Wellness (2016), Valerian in Valerian and the City of a Thousand Planets (2017) and Chris Lynwood in ZeroZeroZero.

Herbert David Kleber was an American psychiatrist and substance abuse researcher. His career, centered on the evidence-based treatment of addiction, focused on scientific approaches in place of punishment and moralisms. His career focused on pathology of addiction to help patients reduce the severe discomforts of withdrawal, avoid relapse and stay in recovery.

Vincent Papale is a former professional American football player. He played three seasons with the Philadelphia Eagles of the National Football League following two seasons with the Philadelphia Bell of the World Football League. Papale's story was the inspiration behind the 2006 film Invincible.

Ebenezer McBurney Byers was a wealthy American socialite, athlete, and industrialist. He won the 1906 U.S. Amateur in golf. He earned notoriety in the early 1930s when he died from multiple radiation-induced cancers after consuming Radithor, a popular patent medicine made from radium dissolved in water.

Franklin D'Olier Reeve was an American academic, writer, poet, Russian translator, and editor. He was also the father of "Superman" actor Christopher Reeve. He was the grandson of the first American Legion national commander, Franklin D'Olier.