List of Famous people born in Paysandú Department, Uruguay

Miguel Ángel Merentiel Serrano is an Uruguayan footballer who plays for Peñarol as a forward.

Marcelo Nicolás Lodeiro Benítez, commonly known as Nicolás Lodeiro, is a Uruguayan footballer who plays as an attacking midfielder for MLS club Seattle Sounders and the Uruguay national team.

Raúl Fernando Sendic Rodríguez is a Uruguayan politician. He was the Vice President of Uruguay from 1 March 2015 to 13 September 2017.

Maximiliano "Maxi" Gómez González is a Uruguayan professional footballer who plays as a striker for La Liga club Valencia and the Uruguay national team.

Egidio Raúl Arévalo Ríos, nicknamed El Cacha, is a Uruguayan professional footballer who plays as a defensive midfielder for Primera División club Sacachispas. He also holds Mexican citizenship.

Andrés Sebastián Soria Quintana commonly known as Sebastián Soria, is a Uruguayan-born, naturalized Qatari professional footballer who plays as a striker for Al-Arabi and the Qatar national team. He was shortlisted for the Asian Footballer of the Year award in 2008. He currently holds the record for the fastest goal scored in AFC Champions League history at 9 seconds – a record which was set in 2013 when he was playing for Lekhwiya.

Walter Alejandro Gargano Guevara is a Uruguayan footballer who plays as a defensive midfielder for Peñarol.

Marcelo Josemir Saracchi Pinto is a Uruguayan footballer who plays as a left back for Turkish Süper Lig club Galatasaray on loan from RB Leipzig, and the Uruguay national team.

Maximiliano Joel Falcón Picart is a Uruguayan footballer who plays as a defender for Colo-Colo in the Chilean Primera División.

Daniel Marx is a former American football fullback. He played college football at Stanford. He led Stanford to single-game rushing totals of 350-plus yards on three occasions over his final two seasons, blocking for Heisman runner-ups Christian McCaffrey and Bryce Love. He signed with the Atlanta Falcons as an undrafted free agent in 2018.