List of Famous people born in Otjozondjupa Region, Namibia

Vekuii Reinhard Rukoro was a Namibian lawyer, businessman, and Paramount Chief of the Herero people. He also served in Namibia's Parliament from 1989 to 2000 and, in Cabinet, as Attorney General of Namibia from 1995 to 2000. Rukoro died on 18 June 2021 of COVID-19.

Hage Gottfried Geingob is the third and current president of Namibia, in office since 21 March 2015. Geingob was the first Prime Minister of Namibia from 21 March 1990 to 28 August 2002, and served as Prime Minister again from 4 December 2012 to 21 March 2015. Between 2008 and 2012 Geingob served as Minister of Trade and Industry. He is also the current president of the ruling SWAPO Party since his election to the position in November 2017.

Dan Craven is a Namibian racing cyclist, who last rode for Namibian amateur team NCCS Cycling Team. He is the grandson of Danie Craven, the South African rugby union icon.

Carl-Hermann Gustav "Calle" Schlettwein is a Namibian politician who has served in the country's cabinet since 2012. In March 2020, he was appointed the Minister of Agriculture, Water and Land Reform after serving as the Minister of Finance from 2015 to 2020 and previously as the Minister of Trade and Industry from 2012 to 2015.