List of Famous people born in Orangeburg, United States of America

Robert Phillips Corker Jr. is an American businessman and politician who served as a United States Senator from Tennessee from 2007 to 2019. A member of the Republican Party, he served as Chair of the Senate Foreign Relations Committee from 2015 to 2019.

Shelton J. Benjamin is an American professional wrestler currently signed to WWE, performing on the Raw brand. He is a part of The Hurt Business alongside MVP, Bobby Lashley and Cedric Alexander and is one half of the current WWE Raw Tag Team Champions with Cedric Alexander in their first reign as a team and Benjamin's third reign overall.

Jonathan Brice Johnson is an American professional basketball player for BC Budivelnyk of the Ukrainian Basketball SuperLeague. He played college basketball for North Carolina, graduating in 2016. He was selected in the first round by the Los Angeles Clippers in the 2016 NBA draft.

Adrienne Monique Coleman is an American actress, dancer, singer, entrepreneur, and philanthropist best known for her role in Disney's High School Musical movies, in which she plays Taylor McKessie. Coleman also had a recurring role on The Suite Life of Zack & Cody, as a school girl named Mary Margaret. She also competed in the third edition of ABC's Dancing with the Stars, finishing in fourth place. Most recent, Coleman was named the first ever UN Youth Champion for the International Year of Youth and is currently on a world tour to raise awareness of challenges facing youth. Coleman launched her online talk show Gimme Mo' , a show dedicated to empowering today's youth on September 8, 2010.

Shawnee Rebecca Smith is an American actress and singer. She is known for her portrayal of Amanda Young in the Saw franchise and for starring as Linda in the CBS sitcom Becker (1998–2004). She co-starred as Jennifer Goodson, the ex-wife of Charlie Goodson on the FX sitcom Anger Management (2012–2014). In addition to acting, Smith once fronted the rock band Fydolla Ho, with which she toured globally. Later, with actress Missi Pyle, she served as half of Smith & Pyle, a country rock band.

Manish Patel, better known as Manish Dayal, is an American actor. He is best known for his roles as Raj Kher in The CW hit teen series 90210 in the films The Hundred Foot Journey (2014) and Viceroy's House (2017). Since 2018, he has featured as a main cast member of the Fox medical drama series The Resident.

Donald James Randolph, better known by the stage name Don Covay, was an American R&B, rock and roll and soul singer and songwriter most active from the 1950s to the 1970s.