List of Famous people born in Ñuble Region, Chile

Víctor Lidio Jara Martínez was a Chilean teacher, theater director, poet, singer-songwriter and communist political activist tortured and killed during the dictatorship of Augusto Pinochet. He developed Chilean theater by directing a broad array of works, ranging from locally produced plays to world classics, as well as the experimental work of playwrights such as Ann Jellicoe. He also played a pivotal role among neo-folkloric musicians who established the Nueva Canción Chilena movement. This led to an uprising of new sounds in popular music during the administration of President Salvador Allende.

Pablo Alejandro Parra Rubilar is a Chilean footballer who currently plays for Liga MX club Puebla as a midfielder.

Levtaru was a young Mapuche toqui known for leading the indigenous resistance against Spanish conquest in Chile and developing the tactics that would continue to be employed by the Mapuche during the long-running Arauco War. Lautaro was captured by Spanish forces in his early youth, and he spent his teenage years as a personal servant of chief conquistador Pedro de Valdivia, but escaped in 1551. Back among his people he was declared toqui and led Mapuche warriors into a series of victories against the Spanish, culminating in the Battle of Tucapel in December 1553, where Pedro de Valdivia was killed. The outbreak of a typhus plague, a drought and a famine prevented the Mapuche from taking further actions to expel the Spanish in 1554 and 1555. Between 1556 and 1557, a small group of Mapuche commanded by Lautaro attempted to reach Santiago to liberate the whole of Central Chile from Spanish rule. Lautaro's attempts ended in 1557 when he was killed in an ambush by the Spanish.

Bernardo O'Higgins Riquelme was a Chilean independence leader who freed Chile from Spanish rule in the Chilean War of Independence. He was a wealthy landowner of Spanish and Irish ancestry. Although he was the second Supreme Director of Chile (1817–1823), he is considered one of Chile's founding fathers, as he was the first holder of this title to head a fully independent Chilean state.

Agustín Arturo Prat Chacón was a Chilean lawyer and navy officer. He was killed in the Battle of Iquique, during the War of the Pacific.

Arturo Merino Benítez, was an aviator with rank of Commodore, and the founder of both the Chilean Air Force (1930) and LAN Chile (1929) the national airline. Chile's largest airport was named in his honour, Arturo Merino Benítez International Airport. His parents were Pedro Merino Feliú and Clorinda Benítez Labbé. He died from a stroke at age 82, his remains are at the Cementerio General de Santiago.

Marcelo Tomás Barrios Vera, also known as Tomás Barrios Vera, is a Chilean professional tennis player. Barrios has a career high ATP rankings in singles of World No. 135 achieved on 9 May 2022. He has won one Challenger title, at Meerbusch, Germany, in 2021. His best ranking in doubles is World No. 217 achieved on 28 February 2022.

Claudio Arrau León was a Chilean pianist known for his interpretations of a vast repertoire spanning the baroque to 20th-century composers, especially Bach, Beethoven, Schubert, Chopin, Schumann, Liszt and Brahms. He is widely considered one of the greatest pianists of the twentieth century.