List of Famous people born in Makkah Region, Saudi Arabia

Abū Muhammad al-Ḥajjāj ibn Yūsuf ibn al-Ḥakam ibn ʿAqīl al-Thaqafī, known simply as al-Hajjaj ibn Yusuf, was perhaps the most notable governor who served the Umayyad Caliphate. He began his service with the Umayyads under Caliph Abd al-Malik, who successively promoted him as the head of the caliph's shurta, the governor of the Hejaz in 692–694, and the practical viceroy of a unified Iraqi province and the eastern parts of the Caliphate in 694. Al-Hajjaj retained the last post under Abd al-Malik's son and successor al-Walid I, whose decision-making was highly influenced by al-Hajjaj, until his death in 714.

Muhammad bin Nayef bin Abdulaziz Al Saud was the crown prince of Saudi Arabia and first deputy prime minister from 2015 to 2017 and minister of interior from 2012 to 2017. He is a grandson of the founding monarch, King Abdulaziz, and son of Nayef bin Abdulaziz, Crown Prince of Saudi Arabia. Muhammad and Nayef were the first father-son duo in Saudi history to serve as crown prince. Muhammad's uncle King Salman named him as crown prince on 29 April 2015. On 21 June 2017 the king appointed his son Mohammad bin Salman to those offices and relieved Muhammad bin Nayef of all positions.

Fāṭima bint Muḥammad, commonly known as Fāṭima al-Zahrāʾ, was the daughter of the Islamic prophet Muhammad and his wife Khadija. Fatima's husband was Ali, the fourth of the Rashidun Caliphs and the first Shia Imam. Fatima's sons were Hasan and Husayn, the second and third Shia Imams, respectively.

Adnan Khashoggi was a Saudi businessman known for his lavish business deals and lifestyle. He is estimated to have had a peak net worth of around US$4 billion in the early 1980s.

Khadijah bint Khuwaylid, commonly known as Khadija, was the first wife and first follower of the Islamic prophet Muhammad. Khadijah was the daughter of Khuwaylid ibn Asad, a leader of Quraysh tribe in Mecca, and a successful businesswoman in her own right.

Hani Saleh Hasan Hanjour was the Saudi Arabian hijacker-pilot of American Airlines Flight 77, crashing the plane into the Pentagon as part of the September 11 attacks.

Ḥamzah ibn ʿAbd al-Muṭṭalib was a foster brother, companion and paternal uncle of the Islamic prophet Muhammad. He was killed in the Battle of Uhud on 22 March 625. His kunyas were "Abū ʿUmārah" and "Abū Yaʿlā". He had the by-names Asad Allāh and Asad al-Jannah, and Muhammad gave him the posthumous title Sayyid ash-Shuhadāʾ.

Khalid Muhammad Abdallah al-Mihdhar was a Saudi Arabian hijacker. He was one of the five hijackers of American Airlines Flight 77, which was flown into the Pentagon as part of the September 11 attacks.

Amr ibn al-As al-Sahmi was the Arab commander who led the Muslim conquest of Egypt and served as its governor in 640–646 and 658–664. The son of a wealthy Qurayshite, Amr embraced Islam in c. 629 and was assigned important roles in the nascent Muslim community by the Islamic prophet Muhammad. The first caliph Abu Bakr appointed Amr as a commander of the conquest of Syria. He conquered most of Palestine, to which he was appointed governor, and led the Arabs to decisive victories over the Byzantines at the battles of Ajnadayn and Yarmouk in 634 and 636.

Hamza bin Osama bin Mohammed bin 'Awad bin Laden, better known as Hamza bin Laden, was a Saudi Arabian-born member of Al-Qaeda. He was a son of Al-Qaeda leader Osama bin Laden and, following his father's death in 2011, he was described as an emerging leader within the group.