List of Famous people born in Guanajuato, Mexico

José Isidro Guerrero Macías was a Mexican Roman Catholic prelate.

Francisco Moreno Barrón is a Mexican bishop who served as auxiliary bishop in the Arquidiócesis of Morelia from 2002 to 2008 and. On 28 March 2008 Benedict XVI appointed him as the third bishop of Tlaxcala. He was installed in the diocese on 28 May 2008, and has served since then as shepherd of this diocese. On June 16, 2016, Pope Francis appointed him Archbishop of Tijuana.

Leonel "Leo" Manzano is a retired Mexican-American middle-distance track and field athlete specializing in the 1500 m and mile. He was a silver medalist at the 2012 Summer Olympics. Manzano is known for finishing his races with a strong finishing kick.

Carlos Medina Plascencia is a Mexican politician affiliated with the conservative National Action Party (PAN). He is a former mayor of León, senator and interim governor of Guanajuato. He was the President of the Chamber of Deputies in 1999. In 2005 he ran for president of the PAN but lost against Manuel Espino.

José Ulises Macías Salcedo, Archbishop emeritus of the Archdiocese of Hermosillo, was born in León, Guanajuato, Mexico, on October 29, 1940.