List of Famous people born in Distrito Nacional, Dominican Republic

Anaís Martínez is a Latin Grammy Award-nominated Dominican-American singer from Santo Domingo, Dominican Republic. She rose to fame after winning the Puerto-Rican singing competition show Objetivo Fama in 2005.

Eduardo Michelle Núñez Méndez is a Dominican professional baseball infielder who is currently a free agent. He previously played for the New York Yankees, Minnesota Twins, San Francisco Giants and Boston Red Sox. Although shortstop is his primary position, Núñez serves as a utility infielder, and played in the outfield for the Yankees as well.

Arismendy Alcántara is a Dominican professional baseball center fielder and second baseman for the Hokkaido Nippon-Ham Fighters of Nippon Professional Baseball (NPB). Alcántara signed as an international free agent with the Chicago Cubs in 2008 as a shortstop. He previously played in Major League Baseball (MLB) for the Cubs, Oakland Athletics, and Cincinnati Reds.

Francisco Liriano Casillas is a Dominican professional baseball relief pitcher in the Toronto Blue Jays organization. He has played in Major League Baseball (MLB) for the Blue Jays, Minnesota Twins, Chicago White Sox, Pittsburgh Pirates, Houston Astros, and Detroit Tigers. Liriano was an MLB All-Star in 2006, and is a two-time winner of the MLB Comeback Player of the Year Award.

Gregory Polanco, nicknamed "El Coffee", is a Dominican professional baseball right fielder who is a free agent. He made his Major League Baseball (MLB) debut in 2014 for the Pittsburgh Pirates.

José Ramon Marmolejos, sometimes referred to as José Marmolejos-Diaz, is a Dominican professional baseball first baseman and outfielder for the Tohoku Rakuten Golden Eagles of Nippon Professional Baseball (NPB). He previously played in Major League Baseball (MLB) for the Seattle Mariners.

Alejandro Mejía is a Dominican professional baseball first baseman and third baseman for the Hiroshima Toyo Carp of Nippon Professional Baseball (NPB).

Carlos Santana, nicknamed "Slamtana," is a Dominican-American professional baseball designated hitter, and first baseman for the Kansas City Royals of Major League Baseball (MLB). He made his MLB debut with the Cleveland Indians on June 11, 2010, and also played the 2018 season with the Philadelphia Phillies. In international competition, he has participated with the Dominican Republic national team, winning the gold medal in the 2013 World Baseball Classic (WBC). Noted for plate discipline and power, Santana has also emerged as an excellent defender at first base. He stands 5 feet 11 inches (1.80 m) tall, weighs 210 pounds (95 kg), throws right-handed and is a switch hitter.

Aristides Aquino Núñez is a Dominican professional baseball outfielder for the Cincinnati Reds of Major League Baseball (MLB). His nickname is The Punisher.

Octavio Eduardo Dotel Diaz is a Dominican former professional baseball pitcher. Dotel played for thirteen major league teams, the second most teams played for by any player in the history of Major League Baseball (MLB), setting the mark when he pitched for the Detroit Tigers on April 7, 2012, breaking a record previously held by Mike Morgan, Matt Stairs, and Ron Villone. Edwin Jackson broke this record in 2019. He was a member of the Houston Astros for 5 seasons.