List of Famous people born in Castile-La Mancha, Spain

Fernando Alarza is a Spanish triathlete. He competed in the men's event at the 2016 Summer Olympics. In 2015 he was part of ECS Triathlon team.

Domingo González Mateos, better known as "Dominguín", was a Spanish bullfighter, who earned a reputation of one of the finest matadors of his time. He was born in Quismondo, Castile-La Mancha and died in Madrid.

José María Cruz Novillo is a Spanish sculptor, engraver, painter and designer.

Juan Carlos Martín Corral, known as Juan Carlos, is a Spanish professional footballer who plays for Girona FC as a goalkeeper.

Fernando de Rojas was a Spanish author and dramatist, known for his only surviving work, La Celestina, first published in 1499. It is variously considered "the last work of the Spanish Middle Ages or the first work of the Spanish Renaissance".

Francisco de Aguirre was a Spanish conquistador who participated in the conquest of Peru, Bolivia, Chile and Argentina.

Antonio Pérez (1534–1611) was a Spanish statesman, secretary of king Philip II of Spain.

Jesús Reguillos Moya, known as Limones, is a Spanish professional footballer who plays for CD Mirandés as a goalkeeper.

Frederick of Castile, in Spanish Fadrique (1223–1277), was a younger son (infante) of King Ferdinand III of Castile by his first wife, Elisabeth of Hohenstaufen. He was born in Guadalajara.

Eleanor of Toledo, born Doña Leonor Álvarez de Toledo y Osorio, was a Spanish noblewoman and Duchess of Florence as the first wife of Cosimo I de' Medici. A keen businesswoman, she financed many of her husband's political campaigns and important buildings like the Pitti Palace. She ruled as regent of Florence during his frequent absences and founded many Jesuit churches. She is credited with being the first modern first lady or consort.