List of Famous people born in Castile and León, Spain

Alphonsus (Alonso) Rodriguez, born in 1538 at Valladolid, Spain, and died 21 February 1616 at Seville, was a Spanish Jesuit priest and spiritual writer of renown. His writings, a single book, underline much the ascetical dimension of religious life.

Manuel Quintano Bonifaz (1699–1774) was a Spanish cleric who was Grand Inquisitor of Spain from 1755 to 1774.

Rafael Calleja Gómez was a Spanish composer, best known for the song "Adiós Granada".

Manuel Ruiz Zorrilla was a Spanish politician. He served as Prime Minister of Spain for a little over ten weeks, in the summer of 1871, and again for eight months, between June 1872 and February 1873.

Alonso de Zuazo was a Spanish lawyer and colonial judge and governor in New Spain and in Santo Domingo. He served in New Spain during the period of Hernán Cortés's government and before the appointment of the first viceroy. He was a member of all of the various triumvirates that governed the colony between October 12, 1524 and May 23, 1525, in the absence of Cortés.

Gabriel von Salamanca was a Spanish nobleman who served as general treasurer and archchancellor of the Habsburg archduke Ferdinand I of Austria from 1521 to 1526. He was elevated to a Count of Ortenburg in 1524.

Alonso de Fonseca y Ulloa was a Roman Catholic prelate who served as Bishop of Ávila (1445–1454), Archbishop of Seville, and Archbishop of Santiago de Compostela (1465–1469).

Juan Hernández Saravia was a high-ranking Spanish military officer of the Republican government forces during the Spanish Civil War.