List of Famous people born in Castile and León, Spain

Conrado San Martín Prieto was a Spanish actor with a long and prolific career. He made his film debut in 1941 and was particularly popular during the 1950s.

John II, called the Great or the Faithless, was King of Aragon from 1458 until his death. As the husband of Queen Blanche I of Navarre, he was King of Navarre from 1425. He was the son of King Ferdinand I of Aragon and Eleanor of Alburquerque. John was also King of Sicily from 1458 to 1468.

Alfonso XI, called the Avenger, was the king of Castile, León and Galicia. He was the son of Ferdinand IV of Castile and his wife Constance of Portugal. Upon his father's death in 1312, several disputes ensued over who would hold regency, which were resolved in 1313.

Isabella Clara Eugenia, sometimes referred to as Clara Isabella Eugenia, was sovereign of the Spanish Netherlands in the Low Countries and the north of modern France with her husband, Archduke Albert VII of Austria. Their reign is considered the Golden Age of the Spanish Netherlands. Isabella was one of the most powerful women in 16th- and 17th-century Europe.

María Luisa Ponte Mancini was a Spanish actress. She appeared in over 135 films and television shows between 1952 and 1995. She appeared in the 1977 film Black Litter, which was entered into the 27th Berlin International Film Festival.

Berengaria was queen regnant of Castile in 1217 and queen consort of León from 1197 to 1204. As the eldest child and heir presumptive of Alfonso VIII of Castile, she was a sought after bride, and was engaged to Conrad, the son of Holy Roman Emperor Frederick I Barbarossa. After his death, she married her cousin, Alfonso IX of León, to secure the peace between him and her father. She had five children with him before their marriage was voided by Pope Innocent III.

Hernando de Acuña, a native of Valladolid, was a Spanish poet and translator of the Spanish Golden Age. He was admired by Emperor Charles V for both his military and literary talents.

Jesús Martín-Barbero was a Spanish-Colombian communication scientist.

José Manuel Aira Lindoso is a Spanish former footballer who played as a central defender, and the manager of Marbella FC.

Luis Tudanca Fernández is a Spanish Socialist Workers' Party (PSOE) politician who has been the party's Secretary General in Castile and León since 2014. He has been Leader of the Opposition in the Cortes of Castile and León since the 2015 elections, and was previously in the Congress of Deputies between 2008 and 2015.