List of Famous people with last name Ospina

David Ospina Ramírez is a Colombian professional footballer who plays as a goalkeeper for Serie A club Napoli and the Colombia national team.

Jorge Iván Ospina is a former Colombian Senator and current mayor of Santiago de Cali, the third largest city in Colombia and the economic hub for Southwestern Colombia. Ospina is also a doctor who has worked in the hospital located in the University of Valle, known as the Hospital Universitario del Valle Evaristo Garcia. Ospina's father, Ivan Marino Ospina, was a guerrilla fighter and co-founder of the revolutionary group 19th of April Movement (M-19).

Dalivier Ospina Navarro is a Colombian cyclist, who last rode for UCI Continental team Coldeportes–Zenú–Sello Rojo. He rode in the 2013 Giro d'Italia.