List of Famous people with last name O-brien

Mark O'Brien was an American journalist, poet, and advocate for the disabled. He has been the subject of two films: Breathing Lessons: The Life and Work of Mark O'Brien, which won an Academy Award in 1997, and The Sessions in which he was portrayed by John Hawkes, a film that won the audience award in the U.S. Dramatic category at the Sundance Film Festival in 2012.

William Smith O'Brien was an Irish nationalist Member of Parliament (MP) and leader of the Young Ireland movement. He also encouraged the use of the Irish language. He was convicted of sedition for his part in the Young Irelander Rebellion of 1848, but his sentence of death was commuted to deportation to Van Diemen's Land. In 1854, he was released on the condition of exile from Ireland, and he lived in Brussels for two years. In 1856 O'Brien was pardoned and returned to Ireland, but he was never active again in politics.

Captain Edward Dominic O'Brien was an Irish law enforcement official and British Army officer.

Eamon Joseph O'Brien was an American actor. In a career spanning nearly four decades, he received an Academy Award, two Golden Globe Awards, and two stars on the Hollywood Walk of Fame.