List of Famous people born in Villa Clara Province, Cuba

Francisco Alejandro Gattorno Sánchez, better known in the show business world plainly as Francisco Gattorno, is a Cuban-Mexican actor. He owns property in Coconut Grove, Miami, Florida. Hijas De la Luna Antagonist

Yuniesky Betancourt Pérez is a Cuban professional baseball shortstop. Betancourt has played in Major League Baseball (MLB) for the Milwaukee Brewers, Seattle Mariners, and Kansas City Royals. He played in the Cuban National Series for Villa Clara before he defected from Cuba. In 2019, he became the first former MLB player to return to the Cuban national baseball system after defecting from the country. However, he never played a game for Villa Clara in 2019. In Cuba, he is nicknamed "Riquimbili".

Andrea Leonora Borrell Hernández is a retired female basketball player from Cuba. She twice competed for her native country at the Summer Olympics, finishing in fifth (1980) and in fourth place (1992) with the Women's National Team.

Melquíades Rafael Ruiz Martínez, is a Cuban-American lobbyist and former politician who served as a United States Senator from Florida from 2005 to 2009 and as general chairman of the Republican Party from November 2006 until October 19, 2007. Previously, Martínez served as the 12th Secretary of Housing and Urban Development under President George W. Bush. Martínez is a Cuban-American and Roman Catholic. He announced he was resigning as general chairman of the Republican National Committee on October 19, 2007.

Yoanka González Pérez is a Cuban racing cyclist, competing in both road cycling and track cycling. She was the 2004 scratch cycling world champion. She is also married to cyclist Pedro Pablo Pérez.