List of Famous people born in Villa Clara Province, Cuba

Miguel Mario Díaz-Canel Bermúdez is a Cuban politician serving as the President of Cuba since 10 October 2019. He was previously President of the Council of State of Cuba from 2018 to 2019 and First Vice President from 2013 to 2018. He has been a member of the Politburo of the Communist Party of Cuba since 2003, and he served as Minister of Higher Education from 2009 to 2012; he was promoted to the post of Vice President of the Council of Ministers in 2012. A year later, on 24 February 2013, he was elected as First Vice President of the Council of State.

Dayán Viciedo Pérez is a Cuban professional baseball infielder for the Chunichi Dragons of the Nippon Professional Baseball League (NPB). He has played in Major League Baseball (MLB) for the Chicago White Sox.

Aleida March Torres is a Cuban revolutionary who was Ernesto "Che" Guevara's second wife, and a member of Fidel Castro's Cuban army.

Rodolfo M. Árias is a retired minor league baseball catcher and former Major League Baseball coach. He served as the bullpen catcher for the Baltimore Orioles of Major League Baseball. He has also served in this capacity for the Florida Marlins and New York Yankees. His father is Rudy Árias.

Bernardo "Benny the Kid" Paret was a Cuban welterweight boxer who won the World Welterweight Championship twice in the early 1960s.

Yandy Díaz Fernandez is a Cuban professional baseball third baseman and outfielder for the Tampa Bay Rays of Major League Baseball (MLB). He previously played for the Cleveland Indians.

Adrián Di Monte is a Cuban television actor and singer.

Francisco Fabián Céspedes Rodríguez, also known as Pancho Céspedes is a Grammy-nominated Latin American singer, musician, and songwriter born in Santa Clara, Cuba. Céspedes is currently a naturalized Mexican. He is most known for his 1998 song, "Vida Loca".

Leonys Martín Tápanes, nicknamed "Ikadi", is a Cuban-American professional baseball center fielder for the Chiba Lotte Marines of Nippon Professional Baseball (NPB). Born in Cuba, he played locally for Villa Clara of the Cuban National Series, and for the Cuban national baseball team in international competitions, including the 2009 World Baseball Classic.

Raquel Olmedo is a Cuban-born Mexican actress and at one time singer. She started her career in her native Cuba before moving to Mexico in 1959.