List of Famous people born in Valle del Cauca Department, Colombia

Reinaldo Lenis Montes is a Colombian footballer currently playing for Chilean club Universidad de Chile.

Jorge Iván Ospina is a former Colombian Senator and current mayor of Santiago de Cali, the third largest city in Colombia and the economic hub for Southwestern Colombia. Ospina is also a doctor who has worked in the hospital located in the University of Valle, known as the Hospital Universitario del Valle Evaristo Garcia. Ospina's father, Ivan Marino Ospina, was a guerrilla fighter and co-founder of the revolutionary group 19th of April Movement (M-19).

Cristian Alexis Borja González is a Colombian footballer who plays as a defender for Portuguese club Braga. Mainly a left-back, he can also play as a central defender.

Adriana Arboleda is a Colombian model and presenter.

Claudia Blum Capurro is a Colombian psychologist and politician who currently serves as foreign minister. A veteran Senator, she became the first woman to serve as President of the Senate of Colombia. She also served as the 26th Permanent Representative of Colombia to the United Nations.

Fabián Andrés Castillo Sánchez is a Colombian footballer who currently plays as a winger for Liga MX club Tijuana.

Adolfo José Valencia Mosquera is a Colombian retired footballer who played as a striker.

Freddy Eusebio Rincón Valencia is a retired Colombian footballer who played 84 games for the Colombia national team between 1990 and 2001. A versatile midfielder he was capable of playing on the left, in the centre or as an attacking midfielder.

Julio Alberto Ríos Gallego is a Colombian engineer, lecturer, mentor, professor of Mathematics and Physics.

Diana Hoyos is a Colombian actress and singer, known for her starring role in the Caracol Televisión telenovela Oye bonita. She is also known in her native country for other productions such as Amar y temer, El Chivo, and Sinú, río de pasiones.