List of Famous people born in Valle del Cauca Department, Colombia

Juan Sebastián Cabal Valdés is a Colombian professional tennis player specialising in doubles. His current ranking in men's doubles is No. 2, and he has also reached world No. 184 in singles. He has won three Grand Slam doubles titles in his career, in 2017 he won the mixed doubles title at the Australian Open, partnering Abigail Spears of the US, and two years later he won his first men's doubles Grand Slam title, winning the 2019 Wimbledon title and 2019 US Open title alongside countryman and regular doubles partner, Robert Farah.

Eileen Moreno Estrada is a Colombian television actress best known in her native country for her roles in Colombian telenovelas. Moreno was born in Palmira, Valle del Cauca, Colombia, and her most prominent television roles have been in La viuda negra as Griselda Blanco, in her youth stage, and Mariana Durán in the biographical drama series El Chivo, both series generally produced by RTI Producciones.

John Stiven Mendoza Valencia is a Colombian professional footballer who plays as a forward for French club Amiens and the Colombia national team.

Johan Andrés Mojica Palacio is a Colombian professional footballer who plays for La Liga club Elche, on loan from Segunda División club Girona FC, and the Colombia national team. Mainly a left back, he can also play as a left winger.

Diana Trujillo is a Colombian aerospace engineer at the NASA Jet Propulsion Laboratory. She is Mission Lead for the Mars Curiosity rover.

Carolina Gómez Correa is a Colombian actress, presenter and model, who held the title of Miss Colombia 1993 and placed 1st Runner-Up at Miss Universe 1994. She currently holds the record for the highest score in the Evening Gown competition in the Miss Universe pageant history.

Gabriela Tafur Náder is a Colombian lawyer, model and beauty pageant titleholder who was crowned Miss Colombia 2018. She represented Colombia at Miss Universe 2019 and placed in the Top 5.

Juan Carlos Ramírez Abadía is a drug trafficker who, until his capture, was one of the leaders of the North Valley Cartel, who was wanted on drug smuggling, murder and RICO charges in the United States of America. In addition to the trafficking of cocaine, it is believed Ramírez also participated in money laundering and trafficking of heroin. Through Ramírez’ illegal enterprise, he has amassed a fortune estimated at $1.8 billion by the US Department of State. He has been cited as "... one of the most powerful and most elusive drug traffickers in Colombia" by Adam J. Szubin, Director of the U.S. Department of the Treasury's Office of Foreign Assets Control (OFAC).

Andrés Parra Medina is a Colombian film and television actor. He is best known for portraying the drug lord Pablo Escobar in the Canal Caracol TV series Pablo Escobar, el patrón del mal.

Nicolás Benedetti Roa is a Colombian professional footballer who plays as an attacking midfielder for Liga MX club América.