List of Famous people born in Santiago Metropolitan Region, Chile

Maite Orsini Pascal is a Chilean lawyer and politician, and former actress and model.

José Piñera Echenique is a Chilean economist, one of the famous Chicago Boys, who served as minister of Labor and Social Security, and of Mining, in the military dictatorship of Augusto Pinochet. He is the architect of Chile's private pension system based on personal retirement accounts. Piñera has been called "the world's foremost advocate of privatizing public pension systems" as well as "the Pension Reform Pied Piper". He is now Distinguished Senior Fellow at the Cato Institute, a libertarian think tank based in Washington, President of the International Center for Pension Reform based in Santiago, Senior Fellow at the Italian libertarian think tank Istituto Bruno Leoni, and member of the Advisory Board of the Vienna-based Educational Initiative for Central and Eastern Europe. He has a master's degree and a Ph.D. in Economics from Harvard University. Piñera is a Board Member in Chile and an active supporter of SOS Children's Villages, the largest orphan and abandoned children's charity in the world. Today, Piñera is director of the magazine Economía y Sociedad, that was relaunched in November 2016.

Cecilia Pérez Jara of Chile in the government of Sebastián Piñera. Between 2011 and 2012 she was intendant of the Santiago Metropolitan Region.

Felipe Bulnes Serrano is a Chilean lawyer and member of the party National Renewal. He was first Minister of Justice and then he assumed office as Minister of Education following a cabinet shuffle on July 18 amidst the ongoing 2011 Chilean student protests but renounced about six months later on December 29 explaining that he left because a "cycle has finished" and not because he would be fired.

Jorge Humberto González Ríos is a Chilean singer-songwriter, best known for being the leader, vocalist, writer and bassist of the band Los Prisioneros, considered by many to be the most popular rock band in the country.

Joaquín José Lavín Infante is a Chilean politician of the Independent Democratic Union (UDI) party and the current mayor of Las Condes municipality of capital Santiago. Formerly Lavín has also been mayor of Santiago, Minister of Education and Minister of Social Development. He ran for president twice in 1999 and 2005, losing both times.

Iván Luis Zamorano Zamora is a Chilean former professional footballer who played as a striker. Along with Marcelo Salas, Leonel Sánchez and Elias Figueroa he is regarded as one of Chile's most recognized footballers.

María Catalina Pulido Anker is a Chilean actress, model, and television presenter.

Nicolas Monckeberg Díaz is a Chilean politician. He was born in a family of German descent. He completed his secondary education in the Tabancura College in Santiago. He joined the Faculty of Law of the Catholic University of Chile caling of lawyer. He completed a Master of Liberal Arts major at Harvard Extension School.

Fabián Ariel Orellana Valenzuela is a Chilean professional footballer who plays as a winger for Spanish club Real Valladolid and the Chilean national team.