List of Famous people born in Santiago de Cuba Province, Cuba

Vilma Lucila Espín Guillois was a Cuban revolutionary, feminist, and chemical engineer. She helped supply and organize the 26th of July Movement as an underground spy, and took an active role in many branches of the Cuban government from the conclusion of the revolution to her death. As an adamant feminist, Espín helped found the Federation of Cuban Women and promoted equal rights for Cuban women in all spheres of life.

Osmany Juantorena Portuondo is a Cuban-born Italian volleyball player, a member of Cuba national volleyball team in 2003–2006 and current member of Italy national volleyball team and Italian club Cucine Lube Civitanova. Juantorena was bronze medalist of the 2005 World League and silver medalist 2016 Summer Olympics. He is a multiple winner of the CEV Champions League and FIVB Club World Championship with the Italian club Trentino Volley. Juantorena is the record owner of the highest number of Most Valuable Player awards at FIVB Club World Championship, with 4 times.

Desiderio Alberto Arnaz y Alberni II was a Cuban politician and the father of Desi Arnaz.

Héctor Olivera Amaro is a Cuban former professional baseball left fielder. He was part of the Cuban team that won a silver medal at the 2008 Summer Olympics. He has played in Major League Baseball (MLB) for the Atlanta Braves.

Olga Guillot was a Cuban singer who was known as the "queen of bolero." She was a native of the Cuban city of Santiago de Cuba.

José Ángel Nápoles, nicknamed Mantequilla, was a Cuban-born Mexican boxer and a World Welterweight Champion. He is frequently ranked as one of the greatest fighters of all time in that division and is a member of the International Boxing Hall of Fame. His record of the most wins in unified championship bouts in boxing history, shared with Muhammad Ali, was unbeaten for 40 years. After debuting professionally in Cuba, he fought out of Mexico and became a Mexican citizen.

Orestes Destrade Cucuas is a Cuban former professional baseball infielder. He played in Major League Baseball (MLB) for the New York Yankees, Pittsburgh Pirates, and Florida Marlins. Destrade also played in Nippon Professional Baseball (NPB) for the Seibu Lions. He is now a broadcaster for the Tampa Bay Rays. Like Olympic Stadium, he was nicknamed The Big O.

Jorge Mas Canosa was a Cuban-American exile who founded the Cuban American National Foundation and MasTec, a publicly traded company. Regarded within the United States as a powerful lobbyist on Cuban and anti-Castro political positions, he was labeled a "counterrevolutionary" by the Cuban Communist Party. Mas Canosa was the driving force behind the creation of both Radio Marti and TV Marti and was appointed chairman of the advisory panel by President Ronald Reagan. In the early 1960s, he was trained by the CIA for the Bay of Pigs Invasion and was commissioned as a second lieutenant in the United States Army. Under his leadership, the CANF received criticism for its role in covert operations in Cuba. In 1998, the New York Times published several articles on his relationship with Luis Posada Carriles.

Miguelina Cobián Hechevarria was a Cuban sprinter. She was a member of the 4 x 100 metres relay team that won a silver at the 1968 Summer Olympics, the first Olympic medal ever achieved by Cuban women.

Alberto Juantorena is a Cuban former runner. He is the only athlete to win both the 400 and 800 m Olympic titles, which he achieved in 1976. He was ranked as world's best runner in the 400 m in 1974 and 1976–1978, and in the 800 m in 1976–77, and was chosen as the Track & Field News Athlete of the Year in 1976 and 1977.