List of Famous people born in Santa Fe Province, Argentina

Luciano "Lucho" Acosta, is an Argentine football attacking midfielder who currently plays for Liga MX club Atlas.

Mateo Pablo Musacchio is an Argentine footballer who plays as a central defender for Italian club Lazio.

Edgardo Bauza is an Argentine former footballer, currently manager. Before taking up management, he played over 300 games for Rosario Central. He also played for Independiente in Argentina, Atlético Junior in Colombia and Veracruz in Mexico.

Jonathan Jesús Bauman is an Argentine professional footballer who plays as a forward for Quilmes.

Renzo Olivo is an Argentine professional tennis player. He competes mainly on the ATP Challenger Tour and ITF Futures, both in singles and doubles. In Bastad he made it through three rounds of qualifying to reach his first ATP tour main draw, where he reached the quarterfinals, defeating 2nd seed Tommy Robredo. He earned the biggest win of his career at the 2017 French Open, when he beat twelfth seed and home favourite Jo-Wilfried Tsonga in four sets.

Carles Puyol Saforcada is a Spanish retired professional footballer who played his entire career for Barcelona. Mainly a central defender, he could also play in either full-back position, mostly as a right-back, and is regarded as one of the best defenders of his generation.

José Ernesto Sosa is an Argentine professional footballer who plays as a midfielder for Süper Lig club Fenerbahçe.

Leandro "Gato" Barbieri was an Argentine jazz tenor saxophonist who rose to fame during the free jazz movement in the 1960s and is known for his Latin jazz recordings of the 1970s. His nickname, Gato, is Spanish for "cat".

Andrés Marcelo Nocioni is an Argentine-Italian retired professional basketball player. He was a two-time All-EuroLeague selection before spending eight seasons in the National Basketball Association (NBA), from 2004 to 2012. Nocioni won a EuroLeague title in 2015, earning the EuroLeague Final Four MVP Award in the process.

José Fernando Bonaparte was an Argentine paleontologist who discovered a plethora of South American dinosaurs and mentored a new generation of Argentine paleontologists . One of the best known Argentine paleontologists, he has been described by paleontologist Peter Dodson as "almost singlehandedly ... responsible for Argentina becoming the sixth country in the world in kinds of dinosaurs".