List of Famous people born in Sancti Spíritus Province, Cuba

Yulieski Gourriel Castillo, commonly known as Yuli Gurriel and nicknamed "La Piña", is a Cuban professional baseball first baseman for the Houston Astros of Major League Baseball (MLB). He previously played for Sancti Spiritus in the Cuban league and the Yokohama DeNA BayStars of Nippon Professional Baseball (NPB). Gurriel is a former member of Cuba's national team. Always a versatile infielder, he has played shortstop, second base, and third base, but has played mostly first base with the Astros.

Lourdes Yunielki Gourriel Castillo Jr. is a Cuban professional baseball left fielder, second baseman and shortstop for the Toronto Blue Jays of Major League Baseball (MLB). He played for Sancti Spíritus and the Industriales of the Cuban National Series before defecting from Cuba. Gurriel was ranked as one of the top international prospects available following his defection.

Frederich Cepeda Cruz is a Cuban professional baseball outfielder for who is currently a free agent. He also played in Nippon Professional Baseball for the Yomiuri Giants.

Anselmo Alliegro y Milá was a Cuban politician who served as the Interim President of Cuba for one day after the departure of the President, General Fulgencio Batista, from the country.