List of Famous people born in Prilep, North Macedonia

Amra Sadiković is a Swiss tennis player. She announced her retirement in May 2014, a few days after her 25th birthday, only to begin playing on the ITF Women's Circuit again 13 months later.

Todor "Toše" Proeski was a Macedonian multi-genre singer, songwriter and actor. Considered a top act of the local Macedonian and Balkan music scene, Proeski's music was popular across multitude of countries of Southeast Europe. He was dubbed the "Elvis Presley of the Balkans" by BBC News. He died in a car crash on the Zagreb–Lipovac A3 highway, near Nova Gradiška in Croatia, on the morning of 16 October 2007, aged 26.

Gyorche Petrov Nikolov born Georgi Petrov Nikolov, was a Bulgarian revolutionary, one of the leaders of the Bulgarian Macedonian-Adrianople Revolutionary Committees. Despite his Bulgarian self-identification, according to the post-World War II Macedonian historiography, he was an ethnic Macedonian.

Ali Fethi Okyar was a Turkish diplomat and politician, who also served as a military officer and diplomat during the last decade of the Ottoman Empire. He was also the second Prime Minister of Turkey (1924–1925) and the second Speaker of the Turkish Parliament after Mustafa Kemal Atatürk.

Darko Krsteski is a retired Macedonian football defender.