List of Famous people born in Prešov Region, Slovakia

Matej Jurčo is a Slovak former professional road bicycle racer, who competed professionally between 2004 and 2015. He is the son of Milan Jurčo, who was also a professional cyclist.

Ladislav Hučko is a Czech hierarch of the Ruthenian Greek Catholic Church.

Eli Moschcowitz was an American doctor best known for his role in discovering thrombotic thrombocytopenic purpura (TTP), which was originally called "Moschcowitz syndrome". He is also known for having an early role in the development of psychosomatic medicine.

Jozef Jarabinský is a former Czechoslovak football player and later a football manager of Carpatho-Rusyn origin.

Martin Otčenáš is a Slovak former biathlete and cross-country skier. He competed at the 2014 Winter Olympics in Sochi, in sprint and individual.

Mikuláš Dzurinda is a Slovak politician who was Prime Minister of Slovakia from 30 October 1998 to 4 July 2006. He is the founder and leader of the Slovak Democratic Coalition (SDK) and then the Slovak Democratic and Christian Union. From 2002 to 2006, his party formed a coalition government with the Christian Democratic Movement, the Alliance of the New Citizen and the Party of the Hungarian Coalition. Mikuláš Dzurinda's 2nd government was labelled as a reformist one, pro-market and most effective one in economic matters in Slovakia since 1993. Carried out reforms included flat tax 19%, pension reform, education financing reform. During his term Slovakia joined both the European Union and NATO.

Pavol Rankov is a Slovak writer. Rankov was born in Poprad and went to school in Bratislava. He studied library science at the Comenius University, graduating in 1987. He then worked at the Slovak National Library in Martin and at the Slovak Pedagogic Library in Bratislava. In 1993, Rankov joined the staff of the Comenius University. He won the European Book Prize as well as the Angelus Award for his novel Stalo sa prvého septembra, translated into English as It Happened on September the First .

Jozef Kožlej is a retired Slovak international professional footballer who played for clubs in Czechoslovakia, Germany, Greece and Cyprus.

Jozef Tomko is a Slovak Cardinal of the Catholic Church. He served as Prefect of the Congregation for the Evangelization of Peoples from 1985 to 2001 and was made a cardinal in 1985.