List of Famous people born in Plzeň Region, Czech Republic

Josef Václav Sládek was a Czech poet, journalist and translator, member of the literary group Lumírovci (cs:Lumírovci), pioneer of children's poetry in Czech lands.

Simon Edler von Lämel was an Austrian-Jewish merchant who devoted his life to bettering the lives of his fellow Jews.

Milena Jelinek was a Czech American screenwriter, playwright and teacher. She wrote the screenplay for the film Forgotten Light, which was awarded three Czech Lions in 1997. Her name is associated with the golden generation of Czech filmmakers, known as Czech New Wave. She was married to the late researcher Frederick Jelinek.

Milan Knížák is a Czech performance artist, sculptor, musician, installation artist, dissident, graphic artist, art theorist and pedagogue of art.

Kurt Raab was a West German stage and film actor, as well as a screenwriter and playwright. Raab is best remembered for his work with German film director Rainer Werner Fassbinder, with whom he collaborated on 31 film projects.

Jaroslav Kvapil was a Czech poet, theatre director, translator, playwright, and librettist. From 1900 he was a director and Dramaturg at the National Theatre in Prague, where he introduced plays by Anton Chekhov, Henrik Ibsen and Maxim Gorky into the repertory. Later he was a director at the Vinohrady Theatre (1921–1928). He wrote six plays, but is today chiefly remembered as the librettist of Antonín Dvořák's Rusalka.

Isaak Löw Hofmann, Edler von Hofmannsthal was an Austrian merchant.