List of Famous people born in Pennsylvania, United States of America

Vito "Babe" Parilli was an American gridiron football player. He played quarterback for five seasons in the National Football League (NFL) and three in the Canadian Football League (CFL) in the 1950s, and then in the American Football League (AFL) for all ten seasons in the 1960s.

Hugh Herr is an American rock climber, engineer, and biophysicist.

Philip Drinker was an industrial hygienist. With Louis Agassiz Shaw, he invented the first widely used iron lung in 1928.

Edwin Garrigues (Gary) Boring was an American experimental psychologist, Professor of Psychology at Clark University and at Harvard University, who later became one of the first historians of psychology. A Review of General Psychology survey, published in 2002, ranked Boring as the 93rd most cited psychologist of the 20th century, tied with John Dewey, Amos Tversky, and Wilhelm Wundt.

John Heysham Gibbon, AB, MD, was an American surgeon best known for inventing the heart–lung machine and performing subsequent open heart surgeries which revolutionized heart surgery in the twentieth century. He was the son of Dr. John Heysham Gibbon Sr., and Marjorie Young Gibbon, and came from a long line of medical doctors including his father, grandfather Robert, great-grandfather John and great-great grandfather.

Barbara Feldon is an American character actress, primarily known for her roles on television. Her most prominent role was that of Agent 99 on the 1960s sitcom Get Smart. She also worked as a model.

Henry John Heinz III was an American businessman and politician from the Commonwealth of Pennsylvania. A Republican, Heinz served in the United States House of Representatives from 1971 to 1977, and in the United States Senate from 1977 until he was killed in a plane crash in Lower Merion Township, Pennsylvania, in 1991.

Elizabeth Janet Gray Vining was an American professional librarian and author who tutored Emperor Akihito of Japan in English while he was crown prince. She was also a noted author, whose children's book Adam of the Road received the Newbery Medal in 1943.

Mary Ellen "Mel" Harris is an American actress best known for her role as Hope Murdoch Steadman in the ABC drama series Thirtysomething (1987–1991), for which she received a Golden Globe nomination in 1990.

Richard Brooks was an American screenwriter, film director, novelist and film producer. Nominated for eight Oscars in his career, he was best known for Blackboard Jungle (1955), Cat on a Hot Tin Roof (1958), Elmer Gantry, In Cold Blood (1967) and Looking for Mr. Goodbar (1977).