List of Famous people born in Palermo, Italy

Prince Leopold of the Two Sicilies was a prince of the Two Sicilies and was known as the Count of Syracuse.

Natalia Ginzburg, was an Italian author whose work explored family relationships, politics during and after the Fascist years and World War II, and philosophy. She wrote novels, short stories and essays, for which she received the Strega Prize and Bagutta Prize. Most of her works were also translated into English and published in the United Kingdom and United States.

Ferdinand II was King of the Two Sicilies from 1830 until his early death in 1859.

Salvatore Schillaci, commonly referred to by his nickname Totò, is an Italian former footballer, who played as a striker. During his club career, he played for Messina (1982–1989), Juventus (1989–1992), Internazionale (1992–1994) and Júbilo Iwata (1994–1997).

Vittorio Emanuele Orlando was an Italian statesman, known for representing Italy in the 1919 Paris Peace Conference with his foreign minister Sidney Sonnino. He was also known as "Premier of Victory" for defeating the Central Powers along with the Entente in World War I. He was also member and president of the Constitutional Assembly that changed the Italian form of government into a Republic. Aside from his prominent political role Orlando is also known for his writings on legal and judicial issues, which number over a hundred works.

Franco Mannino was an Italian film composer, pianist, opera director, playwright and novelist, born in Palermo.

Giovanni Battista Guccia was an Italian mathematician.

Paolo Borsellino was an Italian judge and prosecuting magistrate. From his office in the Palace of Justice in Palermo, Sicily, he spent most of his professional life trying to overthrow the power of the Sicilian Mafia. After a long and distinguished career, culminating in the Maxi Trial in 1986–1987, on 19 July 1992, Borsellino was killed by a car bomb in Via D'Amelio, near his mother's house in Palermo.

Count Alessandro di Cagliostro was the alias of the occultist Giuseppe Balsamo.

Emanuele Paternò, IX Marquess of Sessa was an Italian chemist, discoverer of the Paternò–Büchi reaction.