List of Famous people born in Ōsaka Prefecture, Japan

Tsukasa Aoi is a Japanese gravure idol, actress, television personality, AV idol, and idol singer. Considered one of the most popular AV idols of her generation, Aoi starred over 300 adult films since her start from 2010. Once a leading actress for the famous AV studio Alice Japan, Aoi now exclusively performs for S1 No. 1 Style. She was also a former member of the idol group Ebisu Muscats between 2015 and 2018.

Kazuki Kitamura is a Japanese film and television actor who won the award for best supporting actor at the 21st Yokohama Film Festival for Minazuki, Kyohansha and Kanzen-naru shiiku as well as the CUT ABOVE Award for Excellence in Film at JAPAN CUTS: Festival of New Japanese Film in New York in 2014.

Shinya Yamanaka is a Japanese stem cell researcher, winner of the Nobel Prize. He serves as the director of Center for iPS Cell Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto University; as a senior investigator at the UCSF-affiliated J. David Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also a past president of the International Society for Stem Cell Research (ISSCR).

Takashi Miike is a Japanese filmmaker. He has directed over one hundred theatrical, video and television productions since his debut in 1991. His films run through a variety of different genres, and range from violent and bizarre to dramatic and family-friendly.

Shintaro Fujinami is a Japanese baseball pitcher who plays for Hanshin Tigers of Nippon Professional Baseball's Central League. He was born in Sakai, Osaka, Japan.

Mao Ichimichi is a Japanese actress. She played Luka Millfy/Gokai Yellow in the Super Sentai series Kaizoku Sentai Gokaiger. She started her career as a Japanese idol member of Horipro's HOP Club under the stage name Rio Minami and is a gravure idol. She started an extensive voice acting career under the stage name M・A・O.

Kazuto Ioka is a Japanese professional boxer. He is a four-weight world champion, having held the WBO super-flyweight title since 2019. He previously the unified WBA and WBC mini-flyweight titles between 2011 and 2012, the WBA (Regular) light-flyweight title between 2012 and 2014, and the WBA flyweight title between 2015 and 2017. As of December 2020, he is ranked as the world’s fourth best active super flyweight by BoxRec, and third by The Ring magazine and the Transnational Boxing Rankings Board.

Akihiro Yano is a former Japanese baseball player in Japan's Nippon Professional Baseball. He started his career as the Number 2 Draft pick with the Chunichi Dragons in 1991, and played for the Hanshin Tigers from 1998 until his retirement in 2010.

Gurimu Narita is a Japanese disabled snowboarder. He won gold in Snowboarding at the 2018 Winter Paralympics – Men's banked slalom in the SB-LL2 classification and bronze in Snowboarding at the 2018 Winter Paralympics – Men's snowboard cross.

Ryōsuke Hirata is a Japanese professional baseball outfielder for the Chunichi Dragons in Japan's Nippon Professional Baseball. He has played for the Dragons since 2006.