List of Famous people born in Ōsaka Prefecture, Japan

Masaaki Satake is a Japanese former heavyweight karateka, kickboxer, professional wrestler and mixed martial artist. He is one of the pioneering heavyweight fighters in K-1, having been a member of Kazuyoshi Ishii's Seidokaikan school.

Mika Kurihara Fujitaka is a Japanese basketball player. She represented Japan in the basketball competition at the 2016 Summer Olympics.

Daisuke Nishikawa is a retired Japanese gymnast who competed in the 1988 Summer Olympics and in the 1992 Summer Olympics.

Yūki Mihara is a Japanese model and gravure idol who is affiliated with Discovery Entertainment. She has a bachelor's degree in literature from Rikkyo University.

Kenichi Horie is a Japanese solo yachtsman. Horie first rose to prominence when he was thought to have become the third person to sail solo across the Pacific Ocean in 1962. He has made other significant solo voyages, usually involving boats exhibiting some sort of environmentally friendly theme, including his 2008 voyage across the Western Pacific Ocean in a wave-powered boat.

Yui Watanabe is a Japanese voice actress and singer. She is affiliated with Dandelion.

Mamoru Kishida is a Japanese professional baseball starting pitcher for the Orix Buffaloes in Japan's Nippon Professional Baseball. He made his debut in 2006 and wears the uniform number 14.

Akihito Fujii is a Japanese former professional baseball catcher and current coach for the Hanshin Tigers in Japan's Nippon Professional Baseball. He previously played for the Osaka Kintetsu Buffaloes from 1999 to 2004 and the Tohoku Rakuten Golden Eagles from 2005 to 2010 and the Tigers from 2011 to 2015.

Shōgo Orita is a Japanese professional shogi player ranked 4-dan. Orita is the fourth amateur to obtain professional status without doing so via the Japan Shogi Association's apprentice professional school after he became the second player to pass the Professional Admission Test in February 2020.

Takeshi Konomi is a Japanese manga artist, known for creating the manga series The Prince of Tennis which ran from 1999 to 2008.