List of Famous people born in Matanzas Province, Cuba

Juan Esteban Lazo Hernández is a Cuban politician who has been the President of the National Assembly of People's Power, Cuba's parliament, since 2013. Previously he was Vice-President of the Cuban Council of State. He is a member of the Politburo of the Communist Party of Cuba since 1980 and National Assembly of People's Power member since 1981.

Guillermo Heredia Molina is a Cuban professional baseball outfielder for the New York Mets of Major League Baseball (MLB). He previously played for the Seattle Mariners, Tampa Bay Rays, and the Pittsburgh Pirates. He bats right-handed and throws left-handed.

Osleidys Menéndez Sáez is a retired Cuban track and field athlete who competed in the javelin throw. She was a World and Olympic Champion, and held the world record from 2001 to 2008. Her personal best of 71.70 m remains the North, Central American and Caribbean record and ranks her third on the overall list.

J. R. Ramirez is a Cuban-American actor. He is best known for his series regular role of Detective Jared Vasquez on the NBC series Manifest. Prior, he was a series regular as Julio on the Starz series Power and as Oscar Arocho on the Netflix/Marvel Studios series Jessica Jones. Ramirez also played Ted Grant / Wildcat in a recurring role in the third season of Arrow.

Yadir Drake Dominguez is a Cuban professional baseball outfielder for the Leones de Yucatán of the Mexican Baseball League.