List of Famous people born in Makkah Region, Saudi Arabia

Prince Nayef bin Abdullah was the youngest son of King Abdullah I of Jordan and his second wife, Suzdil Khanum.

Muhammed bin Saud bin Abdulaziz Al Saud was a member of the House of Saud. He was the only son of King Saud to hold high office after his father's deposition in 1964 until his brother Mishaal bin Saud became the governor of Najran Province in 1997.

Abd Allah ibn Hudhafa al-Sahmi was a companion of the Islamic prophet Muhammad. He is best known in Islamic tradition for his role as the courier of a letter from Muhammad to Khusraw Parvez, the King of Persia, and for his imprisonment and torture by Heraclius, the Byzantine Emperor.

Manal al-Sharif (Arabic: منال الشريف‎; born 25 April 1979 is a Saudi women's rights activist who helped start a right to drive campaign in 2011. Wajeha al-Huwaider filmed al-Sharif driving a car as part of the campaign. The video was posted on YouTube and Facebook. Al-Sharif was detained on 21 May 2011, released, and then rearrested the following day. On 30 May, al-Sharif was released on bail, on the conditions of returning for questioning if requested, not driving, and not talking to the media. The New York Times and Associated Press associated the women's driving campaign as part of the Arab Spring and the long duration of al-Sharif's detention due to Saudi authorities' fear of protests.

Hanan Abdulrahim Al-Ahmadi is a Saudi Arabian academic who has been a member of the Consultative Assembly of Saudi Arabia since 2013 and Assistant Speaker since October 2020. She is the first woman to hold the position and in December 2020 became the first woman to chair a session of the body.

Ibtisam Lutfi is a blind Saudi singer. She was born Khayriyyah Qurban in Ta'if in Saudi Arabia, and is one of the first female singers of that country. She began her career singing at wedding feasts in the city of Jeddah in the 1960s, and over the next two decades became famous in her native country as well as in Egypt. In a phone call with Al Arabiya channel in November 2013, she confirmed that she would be returning to her singing career.

Abd Allah ibn Sa'd ibn Abi al-Sarh was an Arab administrator and commander.

Zaynab bint Jahsh was a first cousin and wife of Muhammad and therefore considered by Muslims to be a Mother of the Believers. She had previously been married to Muhammad's adopted son Zayd ibn Harithah.

Abu al-Mughira Ziyad ibn Abihi, also known as Ziyad ibn Abi Sufyan, was an administrator and statesman of the successive Rashidun and Umayyad caliphates in the mid-7th century. He served as the governor of Basra in 665–670 and ultimately the first governor of Iraq and virtual viceroy of the eastern Caliphate between 670 and his death.

Umm Habiba Ramla bint Abi Sufyan was a wife of Muhammad and therefore a Mother of the Believers.