List of Famous people born in Holguín Province, Cuba

Guillermo Cabrera Infante was a Cuban novelist, essayist, translator, screenwriter, and critic; in the 1950s he used the pseudonym G. Caín, and used Guillermo Cain for the screenplay of the cult classic film Vanishing Point (1971).

Juan de Dios Hernández-Ruiz, S.J. is the Titular Bishop of Passo Corese and Auxiliary Bishop of the Archdiocese of Havana. He was appointed by Pope Francis as bishop of the diocese of Pinar del Río, Cuba, on June 5, 2019.

Leuris Pupo Requejo is a Cuban shooter who has represented his nation at four Summer Olympic Games.

Taymara Oropesa Pupo is a Cuban badminton player.

Puntillita was a Cuban popular singer. Puntillita was active in the 1940s and 1950s, and later gained notice when he joined other elderly Cuban musicians to form the Afro-Cuban All Stars and the associated group of singers who recorded the Buena Vista Social Club with American guitarist Ry Cooder.