List of Famous people born in Epirus Region, Greece

Pargalı Ibrahim Pasha, also known as Frenk Ibrahim Pasha, Makbul Ibrahim Pasha, which later changed to Maktul Ibrahim Pasha after his execution in the Topkapı Palace, was the first Grand Vizier of the Ottoman Empire appointed by Sultan Suleiman the Magnificent.

Nikolaos Tsoumanis was a Greek professional footballer who played as a left-back.

Olympias was the eldest daughter of king Neoptolemus I of Epirus, the sister of Alexander I of Epirus, the fourth wife of Philip II, the king of Macedonia and the mother of Alexander the Great. She was extremely influential in Alexander's life and was recognized as de facto leader of Macedon during Alexander's conquests. After her son's death, she fought on behalf of Alexander's son Alexander IV, successfully defeating Adea Eurydice. After she was finally defeated by Cassander, his armies refused to execute her, and he finally had to summon family members of those Olympias had previously killed to end her life. According to the 1st century AD biographer, Plutarch, she was a devout member of the orgiastic snake-worshiping cult of Dionysus, and he suggests that she slept with snakes in her bed.

Reshid Akif Pasha, was an Ottoman statesman during the last decades of the Ottoman Empire. Throughout his career as a politician, Reshid Akif Paşa served as governor, minister of the interior, and in the Council of State. He is also noted for providing important testimony in the aftermath of the Armenian Genocide.

Mehmed Ferid Pasha was an Ottoman statesman of ethnic Albanian background. He served as Grand Vizier of the Ottoman Empire from 15 January 1903 until 22 July 1908, at the time when the Sultan restored the 1876 Constitution following the Young Turk Revolution. Other than Ottoman Turkish he spoke the Albanian, Arabic, French, Italian, and Greek languages.

Mehmed Esad Pasha, known as Mehmet Esat Bülkat after the 1934 Surname Law, was an Ottoman general active during the First Balkan War, where he led the Yanya Corps, and in World War I, where he was the senior Ottoman commander in the Dardanelles Campaign.

Alexandros Karapanos was a Greek politician and diplomat. He was born in Arta (Epirus) and died in Athens.

Thomas Preljubović was ruler of the Despotate of Epirus in Ioannina from 1366 to his death on December 23, 1384. He also held the title of Albanian-slayer after receiving aid from the Ottoman Empire to capture Ioannina from Albanian ruler of the Despotate of Arta, Gjin Bua Shpata, after failing to do so independently. The Albanian Slayer (Ἀλβανοκτόνος).

Athenagoras I, born Aristocles Matthew Spyrou, initially the Greek archbishop in North America, was the 268th Ecumenical Patriarch of Constantinople, from 1948 to 1972.