List of Famous people born in East Macedonia and Thrace, Greece

Manos Hatzidakis was a Greek composer and theorist of Greek music, widely considered as one of the greatest Greek songwriters of all time. His legacy and contribution is widespread among the works of contemporary Greek music, through the second half of the 20th and into the 21st century. He was also one of the main proponents of the "Éntekhno" form of music . In 1960, he received an Academy Award for Best Original Song for his song Never on Sunday from the film of the same name.

Antonis Antoniadis is a former Greek footballer. He scored 243 goals in a career which spanned 22 years. He started his career at 1964 playing for Aspida Xanthi before moving to Panathinaikos on 31 July 1968. Antoniadis scored his first official goal for Panathinaikos on 27 October 1968 in a 1–0 victory over Apollon Athens. When he was playing in Xanthi, he was a goalkeeper because of his height. His nickname is Ο Ψηλός, The Tall.

Soultana (Tania) Tsanaklidou is a Greek artist, both singer and actress, who represented Greece in the Eurovision Song Contest 1978.

Savvas Poursaitidis is a retired Greek-born Cypriot footballer who played mainly as a right back, and the current coach of Cypriot club APOEL.

Giannis Fetfatzidis is a Greek professional footballer who plays as a winger for Qatari club Al-Khor and the Greece national team. Primarily a winger, Fetfatzidis is praised for his dribbling skills, his pace and his ball control.

Aristophon was a Greek painter, mentioned by Pliny the Elder.

Theagenes of Thasos was an ancient Greek Olympian, typically spelled Theogenes before the first century AD.

Aglaophon was an ancient Greek painter, born on the island of Thasos. He was the father and instructor of Polygnotus. He had another son named Aristophon. As Polygnotus flourished before the 90th Olympiad, Aglaophon probably lived around the 70th Olympiad, that is, around the late 6th or early 5th century BC. Quintilian praises his paintings, which were distinguished by the simplicity of their coloring, as worthy of admiration on other grounds besides their antiquity.