List of Famous people born in Cordillera Department, Paraguay

Daniel Librado Azcona Salinas is a Paraguayan footballer who plays for River Plate of the Paraguayan Primera Division.

Arnaldo André is a Paraguayan actor for soap-operas. He spent most of his career in Argentina, where he has been active since 1964. He earned a Martín Fierro award in 2010, and his most recent work was in the Los únicos TV series.

Víctor Hugo Ayala Núñez is a Paraguayan footballer who plays as a midfielder for Gimnasia La Plata in Argentina. He is renowned for his long shot capabilities.

Eusebio Ayala was an intellectual and statesman, and President of Paraguay from 7 November 1921 to 12 April 1923 and again from 15 August 1932 to 17 February 1936. He was a member of the Liberal Party. He was overthrown by Rafael Franco.

Felipe Santiago Benítez Ávalos was the Paraguayan Catholic Archbishop of the Archdiocese of Asuncion from his appointment on May 20, 1989, until his retirement on June 12, 2002.

Pedro Juan Caballero was a leading figure of Paraguayan independence. He was born in Tobatí, a town located Cordillera Department of Paraguay which was then part of the Spanish Viceroyalty of the Río de la Plata. He was one of the major leaders of the Revolution of May 14, 1811, despite being six years younger than the leading figure of Independence period Fulgencio Yegros and 20 years younger than the future dictator of Paraguay José Gaspar Rodríguez de Francia. In 1820 he was accused of being involved in the conspiracy against Francia, and committed suicide in his cell on July 13, 1821. The Paraguayan city of Pedro Juan Caballero is named after him.

Derlis Javier Florentín Noguera was a Paraguayan football striker.