List of Famous people born in Central District, Botswana

Sir Seretse Goitsebeng Maphiri Khama, GCB, KBE was the first President of Botswana, in office from 1966 to 1980.

Isaac Makwala is a Botswana sprinter who specializes in the 400 metres. He was the gold medallist at the Commonwealth Games in 2018. He has also won continental titles at the distance, winning at the 2015 African Games and twice at the African Championships in Athletics. He has represented his country at the 2016 Summer Olympics, three times at the Commonwealth Games, and five times at the World Championships in Athletics. With the Botswana 4 × 400 metres relay team he has won medals at the African Games and Championships, as well as a silver medal at the 2017 IAAF World Relays.

Festus Gontebanye Mogae is a Botswana politician who served as the third President of Botswana from 1998 to 2008. He succeeded Quett Masire as President in 1998 and was re-elected in October 2004; after ten years in office, he stepped down in 2008 and was succeeded by Lieutenant General Ian Khama.

Leetile Disang Raditladi (1910–1971) was a Motswana playwright and poet. He was born in Serowe and got his education in Tiger Kloof, Lovedale and Fort Hare University. A prolific author, he had his first book, a biography of Khama III, accepted for publication while still in high school at Lovedale. This book was later quashed by the Bechuanaland Protectorate authorities and was not published.

Nijel Carlos Amilfitano Amos is a Botswana middle-distance runner who specializes in the 800 metres discipline. He won silver at the 2012 Summer Olympics, which was Botswana's first ever Olympic medal.