List of Famous people born in Central Department, Paraguay

Ángel Rodrigo Romero Villamayor, more commonly known as Ángel Romero, is a Paraguayan professional footballer who plays as a Winger for San Lorenzo. He is the twin brother of Óscar Romero.

Arnaldo Antonio Sanabria Ayala, also known as Tonny Sanabria, is a Paraguayan professional footballer who plays as a striker for Italian club Torino and the Paraguay national team.

Óscar David Romero Villamayor is a Paraguayan professional footballer who plays as an attacking midfielder for Argentinian club San Lorenzo. He is the twin brother of Ángel Romero.

Roque Luis Santa Cruz Cantero is a Paraguayan footballer who plays as a striker for, and captains both Paraguayan club Club Olimpia and Paraguay national team. He is the record goal scorer and has earned over 100 caps for the Paraguay national team, thus he is regarded as one of the best players in the nation's history.

José Luis Félix Chilavert González is a Paraguayan former professional footballer who played as a goalkeeper for Sportivo Luqueño, Guaraní, San Lorenzo de Almagro, Real Zaragoza, Vélez Sarsfield, RC Strasbourg, Peñarol, and the Paraguayan national football team.

Carlos Alberto Gamarra Pavón is a Paraguayan former professional footballer. He captained the Paraguay national team at international level, playing at centre back, and was for a long time the most capped player in Paraguayan football history, having made 110 international appearances and scoring 12 goals. Throughout his career, Gamarra was known for his leadership, physical strength, ability in the air, heading accuracy, and outstanding tackling skills, which made him one of the most respected defenders in South America.

Sergio Ismael Díaz Velázquez is a Paraguayan footballer who plays as a forward for Club América, on loan from Real Madrid, as well as the Paraguay national team.

José Saturnino Cardozo Otazú is a Paraguayan former professional footballer and manager. He played as a striker and spent 10 years of his career playing for Toluca and is the club's all-time top goalscorer. He also managed Toluca in 2013 up to 2016.

Fernando Fabián Fernández Acosta is a Paraguayan professional footballer who plays as a forward for Guaraní.

Federico Javier Santander Mereles is a Paraguayan footballer who plays as a forward for Italian club Bologna and the Paraguay national football team.