List of Famous people born in Castile-La Mancha, Spain

Juan López de Padilla was an insurrectionary leader in the Castilian War of the Communities, where the people of Castile made a stand against policies of the Holy Roman Emperor Charles V and his Flemish ministers.

Ana González Rodríguez, better known as Ana Locking, is a Spanish fashion designer, business woman and photographer. She was born in Toledo and educated in Madrid. She is also a judge on Drag Race España.

John of Ávila was a Spanish priest, preacher, scholastic author, and religious mystic, who has been declared a saint and Doctor of the Church by the Catholic Church. He is called the "Apostle of Andalusia", for his extensive ministry in that region.

Hilario Pino is a Spanish journalist and news anchor and since 2011 is the presenter of the news program Noticias Cuatro in its noon edition.

Enrique "Kike" García Martínez, sometimes known as just Kike, is a Spanish professional footballer who plays as a striker for CA Osasuna.

Diego de Landa Calderón, O.F.M. was a Spanish bishop of the Roman Catholic Archdiocese of Yucatán. Many historians criticize his campaign against idolatry. In particular, he burned almost all the Maya manuscripts (codices) that would have been very useful in deciphering Maya script, knowledge of Maya religion and civilization, and the history of the American continent. Nonetheless, his work in documenting and researching the Maya was indispensable in achieving the current understanding of their culture, to the degree that one scholar asserted that, "ninety-nine percent of what we today know of the Mayas, we know as the result either of what Landa has told us in the pages that follow, or have learned in the use and study of what he told."

Francisco Morales Nieva was a Spanish playwright.

Saint Ildefonsus or Ildephonsus was a scholar and theologian who served as the metropolitan Bishop of Toledo for the last decade of his life. His Gothic name was Hildefuns. In the Ethiopian Orthodox Tewahedo Church he is known as Saint Dexius based on the Ge'ez translation of the legends about his life.

Amparo Pacheco was a Spanish actress.

Gonzalo Pérez de Vargas Moreno is a Spanish handball player for FC Barcelona Lassa and the Spanish national team.