List of Famous people born in Castile-La Mancha, Spain

Andrés Iniesta Luján is a Spanish professional footballer who plays as a central midfielder and is the captain of Japanese club Vissel Kobe. He spent most of his career at Barcelona, where he served as the captain for three seasons. Iniesta is widely considered to be one of the best players of his generation and one of the greatest midfielders of all time.

Pedro Almodóvar Caballero is a Spanish filmmaker, director, screenwriter, producer, and former actor. His films are marked by his employment of certain actors including Antonio Banderas and Penelope Cruz and creative personnel with complex narratives, melodrama, pop culture, popular songs, irreverent humour, strong colours, and glossy décor. Desire, passion, family, and identity are among Almodóvar's most prevalent themes.

Joanna, known historically as Joanna the Mad, was Queen of Castile from 1504 and Queen of Aragon from 1516 to 1555. Modern Spain evolved from the union of these two kingdoms. Joanna was married by arrangement to Philip the Handsome, Archduke of Austria of the House of Habsburg, on 20 October 1496. Following the deaths of her brother, John, Prince of Asturias, in 1497, her elder sister Isabella in 1498, and her nephew Miguel in 1500, Joanna became the heir presumptive to the crowns of Castile and Aragon. When her mother, Queen Isabella I of Castile, died in 1504, Joanna became Queen of Castile. Her father, King Ferdinand II of Aragon, proclaimed himself Governor and Administrator of Castile. In 1506 Archduke Philip became King of Castile jure uxoris, initiating the rule of the Habsburgs in the Spanish kingdoms, and died that same year. Despite being the ruling Queen of Castile, Joanna had little effect on national policy during her reign as she was declared insane and imprisoned in the Royal Convent of Santa Clara in Tordesillas under the orders of her father, who ruled as regent until his death in 1516, when she inherited his kingdom as well. From 1516, when her son Charles I ruled as king, she was nominally co-monarch but remained imprisoned until her death.

Alfonso X was the king of Castile, León and Galicia from 30 May 1252 until his death in 1284. During the election of 1257, a dissident faction chose him to be king of Germany on 1 April. He renounced his claim to Germany in 1275, and in creating an alliance with the Kingdom of England in 1254, his claim on the Duchy of Gascony as well.

Feliciano López Díaz-Guerra is a Spanish professional tennis player on the ATP Tour. He was born in Toledo and now lives in the Spanish capital, Madrid. López achieved his career-high singles ranking of world No. 12 in March 2015.

Jared Dovan Anderson is an American professional boxer who has held the NABF Junior heavyweight title since October 2021. As an amateur he won the 2017 and 2018 U.S. National Championships.

Joseph Maria Kelly is a musician, songwriter, and athlete of Irish-American descent.

María Antonia Abad Fernández MML, known professionally as Sara Montiel, and as Sarita Montiel, was a Spanish singer and actress. She has been called a "sexual, feminist, and gay icon for Francoist Spain."

Juan Ramón Sánchez Guinot was a Spanish actor, singer, sculptor and painter who played Chema the baker in the Spanish Sesame Street co-production Barrio Sésamo.

Berta Collado is a Spanish TV presenter and journalist. She grew up in Navalmoral de la Mata, Cáceres, Spain.