List of Famous people born in Castile and León, Spain

Infante Juan of Spain, Count of Barcelona, also known as Don Juan, was the third son and designated heir of King Alfonso XIII of Spain and Victoria Eugenie of Battenberg. His father was replaced by the Second Spanish Republic, and under his son, Juan Carlos I, a constitutional monarchy was installed.

Juan Ponce de León, commonly known as Ponce de León, was a Spanish explorer and conquistador known for leading the first official European expedition to Florida and serving as the first governor of Puerto Rico. He was born in Santervás de Campos, Valladolid, Spain in 1474. Though little is known about his family, he was of noble birth and served in the Spanish military from a young age. He first came to the Americas as a "gentleman volunteer" with Christopher Columbus's second expedition in 1493.

María Jesús San Segundo Gómez de Cadiñanos, was a Spanish economist, academic, diplomat and politician, minister of Education and Science of Spain between 2004 and 2006.

Ana María Pastor Julián is a Spanish doctor and politician for the People's Party who served as President of the Congress of Deputies from 19 July 2016 to 20 May 2019. Previously she was Minister of Health from 2002 to 2004 and Minister of Public Works from 2011 to 2016. Since 20 May 2019 is the Second Vice President of the Congress of Deputies.

Blanche of Castile was Queen consort of France by marriage to Louis VIII. She acted as regent twice during the reign of her son, Louis IX: during his minority from 1226 until 1234, and during his absence from 1248 until 1252. She was born in Palencia, Spain, 1188, the third daughter of Alfonso VIII, King of Castile, and Eleanor of England.

Agustín García Calvo was a Spanish philologist, philosopher, poet and playwright.

José Luis Corcuera is a Spanish politician who served as interior minister of Spain from 1988 to 1993.

Rosa María Mateo Isasi, is a Spanish journalist and renowned television news anchor during the Transition. Since July 2018, she is the Provisional Sole Administrator of RTVE, the national public radio and television media.

Saint Dominic, also known as Dominic of Osma and Dominic of Caleruega, often called Dominic de Guzmán and Domingo Félix de Guzmán, was a Castilian Catholic priest and founder of the Dominican Order. Dominic is the patron saint of astronomers.

Carlos, Prince of Asturias, also known as Don Carlos, was the eldest son and heir-apparent of King Philip II of Spain. His mother was Maria Manuela of Portugal, daughter of John III of Portugal. Carlos was mentally unstable and was imprisoned by his father in early 1568, dying after half a year of solitary confinement. His fate was a theme in Spain's Black Legend, and inspired a play by Friedrich Schiller and an opera by Giuseppe Verdi.