List of Famous people born in Castile and León, Spain

Diego de Losada y Cabeza de Vaca was a Spanish conquistador and the founder of Santiago de León de Caracas, the current capital of Venezuela.

Domingo de Soto was a Spanish Dominican priest and Scholastic theologian born in Segovia (Spain), and died in Salamanca (Spain), at the age of 66. He is best known as one of the founders of international law and of the Spanish Thomistic philosophical and theological movement known as the School of Salamanca. He is also known for his contributions to Mechanical Physics.

Juan de Torquemada, O.P., , Spanish ecclesiastic, was born at Valladolid, and was educated in that city.

Juan Rodriguez de Fonseca (1451–1524) was a Spanish archbishop, a courtier and bureaucrat, whose position as royal chaplain to Queen Isabella enabled him to become a powerful counsellor to Ferdinand and Isabella, the Catholic Monarchs. He controlled the Casa de Contratación, an agency which managed expeditions to the New World on behalf of the Spanish crown. He later served as the president of the Council of the Indies, when it was founded in 1521. He managed the administration of a number of significant Spanish expeditions including voyages by Christopher Columbus and Magellan's circumnavigation of the earth.

Lope de Barrientos (1382–1469), sometimes called Obispo Barrientos, was a powerful clergyman and statesman of the Crown of Castile during the 15th century, although his prominence and the influence he wielded during his lifetime is not a subject of common study in Spanish history.

Saint Peter de Regalado was a Franciscan and reformer.

Prudencio Sánchez Fernández, commonly known as Pruden was a Spanish association football player who played mainly for Real Madrid. His career started in Salamanca, in the club's first ever season, 1934–35 regional league. The next season, 1939–40, the club was promoted to Segunda División, the second tier in Spain. He then moved to Atlético Madrid, where he scored 33 goals winning the Pichichi Trophy and helping the club win the La Liga title. He then returned to his youth club for 2 years, and after failing to lead the club to promotion, he left for Real Madrid. He spent 5 years in Madrid, failing to win the league title, although he did win two consecutive Copa del Reys, in 1946 and 1947, and scored in both finals. He finished his professional career with one season in Real Zaragoza, in the Tercera División, then the 3rd tier.