List of Famous people born in Castile and León, Spain

Philip II was King of Spain (1556–1598), King of Portugal, King of Naples and Sicily, and jure uxoris King of England and Ireland. He was also Duke of Milan from 1540. From 1555 he was Lord of the Seventeen Provinces of the Netherlands.

Justo Gallego Martínez is a former monk who has been constructing a cathedral building on his own in the town of Mejorada del Campo in the Community of Madrid, Spain, since 1961. Don Justo has named the building Nuestra Señora del Pilar.

Isabella I was Queen of Castile from 1474, and Queen consort of Aragon from 1479, reigning over a dynastically unified Spain jointly with her husband Ferdinand II of Aragon until her death; together they would be known as the Catholic Monarchs. Isabella is considered the first Queen of Spain de facto, being described as such during her own lifetime, although Castile and Aragon de jure remained two different kingdoms until the Nueva Planta decrees of 1707 to 1716.

María Dolores Herrera Arranz MML better known as Lola Herrera is an awarded Spanish actress.

Juan Manuel Mata García is a Spanish professional footballer who plays as a midfielder for Premier League club Manchester United and the Spain national team. He mostly plays as a central attacking midfielder, but he can also play on the wing. Mata is considered by pundits to be one of the best attacking midfielders of his generation.

Rodrigo Díaz de Vivar was a Castilian knight and warlord in medieval Spain. The Moors called him El Cid, which meant the Lord, and the Christians, El Campeador, which is idiomatically translated as "the Master of the Battlefield" in Old Spanish. He was born in Vivar del Cid, a village near the city of Burgos. Díaz de Vivar became well known for his service in the armies of both Christian and Muslim rulers, his exile, and his temporary conquest of Valencia, which became independent for a brief period in the Reconquista. After his death, El Cid became Spain's celebrated national hero and the protagonist of the most significant medieval Spanish epic poem, El Cantar de Mio Cid.

Concepción Velasco Varona OAXS MML, known professionally as Concha Velasco, is a Spanish film actress, theater actress, singer, and television presenter. She was born in Valladolid and she moved to Madrid when she was 10 years old. She worked as a dancer with Manolo Caracol and with Celia Gámez.

Francisco Javier Cuesta Ramos, better known as Frank Cuesta, is a Spanish adventurer, television presenter and tennis coach, who has lived in Bangkok, Thailand for over 20 years. For the past 15 years Frank Cuesta has been fighting illegal animal trafficking and animal abuse in the southeast Asia. In 2012, after being infiltrated into Bear farms in Vietnam as a vet, he showed to the world, the dramatic images of how bears were abused daily, to get their bile for traditional alternative medicines and other curatives with no scientifically proven value. This report then pushed the Vietnamese Government to make an official statement where they promised to abort these activities.

Silvia Alonso Cruz is a Spanish actress. Her debut was as the protagonist of the Telecinco series Tierra de lobos, playing Almudena Lobo. She has participated in different Spanish series such as Amar es para siempre, La que se avecina and Sin identidad.

Pablo Casado Blanco is a Spanish politician and leader of the People's Party (PP). He is a member of the Congress of Deputies in representation of Madrid, having previously represented Ávila between 2011 and 2019. From 2015 to 2018, he also served as vice secretary general of communication of the PP. Since July 2018, he has been the president of the PP.