List of Famous people with last name Eppes

Mary Jefferson Eppes, known as Polly in childhood and Maria as an adult, was the younger of Thomas Jefferson's two daughters with his wife who survived beyond the age of 3. She married a first cousin, John Wayles Eppes, and had three children with him. Only their son Francis W. Eppes survived childhood. Maria died months after childbirth.

John Wayles Eppes was an American lawyer and politician. He represented Virginia in the U.S. House of Representatives from 1803 to 1811 and again from 1813 to 1815. He also served in the U.S. Senate (1817–1819). His positions in Congress occurred after he served in the Virginia House of Delegates representing Chesterfield County (1801–1803).

Francis Wayles Eppes was a planter and slave owner from Virginia who became prominent near and in Tallahassee, Florida. His maternal grandparents were President Thomas Jefferson and his wife Martha; his paternal grandparents were Francis Wayles Eppes VI, also a prominent planter in Virginia, and his wife Elizabeth Wayles, half-sister to Martha Wayles Skelton Jefferson.