List of Famous people born in Western Cape, South Africa

Pieter Mauritz Retief was a Voortrekker leader. Settling in 1814 in the frontier region of the Cape Colony, he assumed command of punitive expeditions in response to raiding parties from the adjacent Xhosa territory. He became a spokesperson for the frontier farmers who voiced their discontent, and wrote the Voortrekkers' declaration at their departure from the colony.

Christiaan Hendrik Persoon was a German mycologist who made additions to Linnaeus' mushroom taxonomy.

Daniël François Malan, PC was a South African politician who served as Prime Minister of South Africa from 1948 to 1954. The National Party implemented the system of apartheid, which enforced racial segregation laws. The foundations of apartheid were firmly laid down during his tenure as Prime Minister.