List of Famous people born in Thessaly Region, Greece

Alberto Israel Errera was a Greek-Jewish officer and a member of the anti-Nazi resistance. He was a member of the Sonderkommando in Auschwitz-Birkenau from May to August 1944.

Vassilis "Billy" Spanoulis is a Greek professional basketball player for Olympiacos of the EuroLeague. A 6 ft 4 in (193 cm) tall combo guard, he is nicknamed Kill Bill, V-Span, and MVP. Spanoulis was named the Balkan Athlete of the Year in 2009, the All-Europe Player of the Year in 2012 and 2013, the Vatican's World Athlete of the Year in 2013 and the EuroLeague MVP the same year. He has earned a record eight All-EuroLeague Team selections. He was also voted the EuroLeague's 2010–2020 Player of the Decade. He is also the EuroLeague's all-time career leader in total points scored.

Theofanis "Fanis" Gekas is a Greek former professional footballer who played as a striker.

Alexis Georgoulis is a Greek actor and politician.

Christos Papoutsis is a Greek socialist politician who has served as Minister for Citizen Protection (2010–12), Mercantile Marine Minister (2000–01) Member of the European Parliament (1984–95) and European Commissioner for Energy and Euratom Supply Agency, Small business and Tourism (1995–1999). He has also served as the Secretary of the Parliamentary Group and Parliamentary Spokesman for the Panhellenic Socialist Movement (PASOK), the majority party in Greece (2009–2010). He also was candidate for Mayor of Athens (2002).

Fani Chalkia, also transliterated as Halkia or Khalkia, is a retired Greek hurdler.

Konstantinos "Kostas" Papanikolaou is a Greek professional basketball player for Olympiacos of the EuroLeague. Standing at 2.04 m tall, he plays at the small forward position. He has previously played in the NBA for the Houston Rockets and Denver Nuggets, and is also a member of the senior Greek national team.