List of Famous people born in Santiago Metropolitan Region, Chile

Marko Zaror Aguad is a Chilean martial artist, actor, and stuntman of Italian and Palestinian descent according to interviews.

Claudio Miranda, ASC is a Chilean cinematographer best known as the Academy Award-winning director of photography on Ang Lee's film Life of Pi and as the director of photography on David Fincher's film The Curious Case of Benjamin Button, the first entirely digitally filmed movie nominated for an Academy Award for Best Cinematography and an American Society of Cinematographers Award. He is also known for his collaborations with American director Joseph Kosinski. He is the second Chilean person to win an Academy Award.

Leonardo Felipe Valencia Rossel is a Chilean footballer who plays as a midfielder for Chilean club Colo-Colo.

Denisse Lillian Laval Soza, better known by her stage name Nicole, is a Chilean singer-songwriter, based in Santiago and Miami.

Esteban Grimalt is a Chilean Olympic volleyball player.

Luis Alberto Jara Cantillana, also known as Lucho Jara, is a Chilean singer, television host and former actor. He has participated in the teleseries De cara al mañana playing as Juan José "El Turco" Aguad, and Los títeres from Canal 13, as Pato.

Blanca Esperanza Lewin Gajardo is a Chilean actress of Jewish origin. She studied at Pontificia Universidad Católica de Chile. She is best known by her role of "Lola Padilla" in the soap opera Lola by Canal 13. She has won awards including Altazor for "Best Actress" three times and Festival de Cine Internacional de Palm Springs.

Felipe Andrés Mora Aliaga is a Chilean footballer who plays as a striker for MLS club Portland Timbers.

Juan de la Cruz Barros Madrid is a Chilean prelate of the Catholic Church. He was Bishop of Osorno from 2015 to 2018. He was Auxiliary Bishop of Valparaíso from 1995 to 2000, Bishop of Iquique from 2000 to 2004, and Military Ordinary of Chile from 2004 to 2015.

Mathías Leonardo Vidangossy Rebolledo is a Chilean professional footballer who currently plays for Deportes Melipilla as an attacking midfielder or winger.