List of Famous people born in Massachusetts, United States of America

Rachael Splaine Rollins is an American lawyer and politician who is the District Attorney of Suffolk County in Massachusetts, which includes the municipalities of Boston, Chelsea, Revere, and Winthrop. Rollins is the first woman to hold the office of Suffolk County D.A. and the first woman of color to serve as a Massachusetts D.A. In July 2021, President Joe Biden nominated Rollins to be the United States Attorney for the District of Massachusetts. She is an advocate for criminal justice reform.

Conan Christopher O'Brien is an American television host, comedian, writer, podcaster, and producer. He is best known for hosting the late-night talk shows Late Night with Conan O'Brien, The Tonight Show with Conan O'Brien, and since 2010, Conan on the cable channel TBS. Prior to his hosting career, he was a writer for Saturday Night Live and The Simpsons.

Michael Andrew Yastrzemski is an American professional baseball outfielder for the San Francisco Giants of Major League Baseball (MLB). Yastrzemski played college baseball for the Vanderbilt Commodores. The Baltimore Orioles selected him in the 14th round of the 2013 MLB draft. He made his MLB debut with the Giants in 2019. He is the grandson of Hall of Famer and Triple Crown winner Carl Yastrzemski.

James Edward "Jes" Staley, is an American banker, and the former group chief executive (CEO) of Barclays. He stood down as CEO on 1 November 2021 and was succeeded by C. S. Venkatakrishnan. Staley has nearly four decades of experience in banking and financial services. He spent 34 years at J.P. Morgan's investment bank, ultimately becoming CEO. In 2013 he moved to BlueMountain Capital, and in December 2015, became CEO of Barclays.

Edward Harrison Norton is an American actor and filmmaker. He has received numerous awards and nominations, including a Golden Globe Award and three Academy Award nominations.

William Frederick Burr is an American stand-up comedian, actor and podcaster. He created and stars in the Netflix animated sitcom F Is for Family (2015–present), played Patrick Kuby in the AMC crime drama series Breaking Bad (2008–2013), and Migs Mayfeld in the Star Wars television series The Mandalorian (2019–present). He co-founded the All Things Comedy network. He has hosted the twice-weekly comedy podcast, titled The Monday Morning Podcast, since May 2007.

John Michael Higgins is an American actor, voice actor and comedian whose film credits include Christopher Guest's mockumentaries, the role of David Letterman in HBO's The Late Shift and a starring role in the American version of Kath & Kim. He portrayed Peter Lovett in the TV Land original sitcom Happily Divorced and provided the voice of Iknik Blackstone Varrick in The Legend of Korra and Mini-Max in Big Hero 6: The Series. He also starred in the NBC sitcom Great News as Chuck Pierce for 2 seasons. He currently hosts the game show America Says, which earned him a 2019 Daytime Emmy Award nomination for Outstanding Game Show Host.

Howard Matthew Moses Long is a former American football defensive end, actor, and sports analyst. He played in the National Football League (NFL) for 13 seasons and spent his entire career with the Raiders franchise in Oakland and Los Angeles. During his tenure as a player, Long was named to eight Pro Bowls and helped the Los Angeles Raiders win a championship in Super Bowl XVIII in 1984. He was inducted into the Pro Football Hall of Fame in 2000.

James Todd Spader is an American actor and producer. He has portrayed eccentric characters in films such as the drama Sex, Lies, and Videotape (1989), the action science fiction film Stargate (1994), the controversial psychological thriller Crash (1996), the erotic romance Secretary (2002) and Steven Spielberg's Lincoln (2012). He also voiced and performed motion-capture of the titular character of Ultron in Avengers: Age of Ultron (2015).

Noah Gordon is an American novelist. He was born in Worcester, Massachusetts.