List of Famous people born in Makkah Region, Saudi Arabia

Abd-al-Dar ibn Qusai forms an important link between his father, Qusai ibn Kilab, the great-great-grandfather of Shaiba ibn Hashim (Abdul-Mutallib) and his own sons, since he is the progenitor of the Banu Abd-al-dar.

Umayya ibn Abd Shams was the son of Abd Shams and is said to be the progenitor of the line of the Umayyad Caliphs. Ibn al-Kalbi says that his name is derived from 'afa', a diminutive of the word for slave-girl and instead of being the legitimate son of Abd Shams, Ibn al-Kalbi claimed that he was adopted by him, The clan of Banu Umayya as well as the dynasty that ruled the Umayyad Caliphate and Caliphate of Córdoba are named after Umayya ibn Abd Shams.

Zayd ibn al-Khaṭṭāb was a companion of the Islamic prophet Muḥammad and a brother of Umar the second Caliph.

KHR. As’ad Syamsul Arifin was an Indonesian ulama and co-founder of Nahdatul Ulama. In 2016, he was declared a National Hero of Indonesia.

Muhammed Saeed Taib is a Saudi Arabian political activist, lawyer, writer, and one of the most prominent liberals in the country. He is best known for his book Prince and Intellectuals (مثقفون وأمير: الشورى وسياسة الباب المفتوح) where he stated his liberal views on the political reforms of Saudi Arabia. The book was published in 1992 and was banned in Saudi Arabia. Taib has recently participated in the Saudi Arabian National Debate.

Dr. Hayat bint Sulaiman bin Hassan Sindi is a Saudi Arabian medical scientist and one of the first female members of the Consultative Assembly of Saudi Arabia. She is famous for making major contributions to point-of-care medical testing and biotechnology. She was ranked by Arabian Business as the 19th most influential Arab in the world and the ninth most influential Arab woman. In 2018, she was listed as one of BBC's 100 Women.

Hatoon Ajwad al-Fassi is a women's rights activist and an associate professor of women's history at King Saud University in Saudi Arabia, where she has been employed since 1989 and at the International Affairs Department at Qatar University. At the university, al-Fassi carries out historical research. Al-Fassi claims from her research into the pre-Islamic Arabian kingdom of Nabataea that women in the kingdom had more independence than women in modern Saudi Arabia. Al-Fassi was active in women's right to vote campaigns for the 2005 and 2011 municipal elections and was active in a similar campaign for the 2015 municipal elections. She was arrested in late June 2018 as part of a crackdown on women's activists and was released in early May 2019.

Yazid ibn Abi Sufyan was a leading Arab general at the time of the Islamic conquest of Syria, and the elder brother of Muawiya ibn Abi Sufyan.

Uqba ibn Abi Mu'ayt was one of the principal adversaries of Islam. He was a Quraysh leader and a member of the Banu 'Abdu Shams clan of Quraish tribe.

Hakīm ibn Hizām was a companion of the Islamic prophet Muhammad and a nephew of Khadija.